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Role of the Choroid Plexus in Health and Disease: Physiology in Health and Disease

Editat de Jeppe Praetorius, Bonnie Blazer-Yost, Helle Damkier
en Limba Engleză Hardback – 18 apr 2020
This book highlights the importance of the choroid plexus, which forms the blood-cerebrospinal fluid barrier and is the site of the major production of the cerebrospinal fluid (CSF). The authors show that this barrier is crucial for maintaining important compositional differences between the blood plasma and the CSF. The choroid plexus epithelial cells also prevent the spread of infectious agents and other blood-borne entities to the brain tissue. 
Chapter topics range from the production of CSF by electrolyte regulation in the choroid plexus, to details on the selectively transporting nature of this barrier. Further, the authors elaborate on the important roles of CSF in sustaining brain health by providing hydration, solutes, and nutrients to the brain tissue. Readers will also learn how CSF circulates signaling molecules within the compartments of the brain and removes waste products from the brain tissue. Elucidating the regulation of these processes in thechoroid plexus is not only important for the readers’ understanding of normal brain development and function, but is also crucial for resolving a variety of cerebral challenges that lead to brain edema, as well as developing treatments for diseases. The book discusses disease models like hydrocephalus, sleep disorders, and age-related dementia.
Its comprehensive coverage makes this volume a valuable resource for researchers in cell and neurophysiology, as well as graduate students of the neurosciences.
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Specificații

ISBN-13: 9781071605356
ISBN-10: 1071605356
Ilustrații: VI, 287 p. 65 illus., 46 illus. in color.
Dimensiuni: 155 x 235 mm
Greutate: 0.59 kg
Ediția:1st ed. 2020
Editura: Springer Us
Colecția Springer
Seria Physiology in Health and Disease

Locul publicării:New York, NY, United States

Cuprins

Structure of the Mammalian Choroid Plexus.- Blending Established and New Perspectives on Choroid Plexus-CSF Dynamics.- A Frog Model for CSF Secretion.- Cotransport of Water in the Choroid Plexus Epithelium: From Amphibians to Mammals.- The Significance of the Choroid Plexus for Cerebral Iron Homeostasis.- Acid/Base Transporters in CSF Secretion and pH Regulation.- TRPV4, a Regulatory Channel in the Production of Cerebrospinal Fluid by the Choroid Plexus.- Neuroprotective Mechanisms at the Blood-CSF Barrier of the Developing and Adult Brain.- Roles of the Choroid Plexus in Aging.- Choroid Plexus Tumors.- Roles of the Choroid Plexus in CNS Infections.- Hydrocephalus.

Notă biografică

Jeppe Praetorius
Department of Biomedicine
Aarhus University
Aarhus
Denmark


Bonnie Blazer-Yost
Department of Biology
Indiana University – Purdue University Indianapolis
Indianapolis Indiana
USA


Helle Damkier
Department of Biomedicine
Aarhus University
Aarhus
Denmark



Textul de pe ultima copertă

This book highlights the importance of the choroid plexus, which forms the blood-cerebrospinal fluid barrier and is the site of the major production of the cerebrospinal fluid (CSF). The authors show that this barrier is crucial for maintaining important compositional differences between the blood plasma and the CSF. The choroid plexus epithelial cells also prevent the spread of infectious agents and other blood-borne entities to the brain tissue.  Chapter topics range from the production of CSF by electrolyte regulation in the choroid plexus, to details on the selectively transporting nature of this barrier. Further, the authors elaborate on the important roles of CSF in sustaining brain health by providing hydration, solutes, and nutrients to the brain tissue. Readers will also learn how CSF circulates signaling molecules within the compartments of the brain and removes waste products from the brain tissue. Elucidating the regulation of these processes in the choroidplexus is not only important for the readers’ understanding of normal brain development and function, but is also crucial for resolving a variety of cerebral challenges that lead to brain edema, as well as developing treatments for diseases. The book discusses disease models like hydrocephalus, sleep disorders, and age-related dementia.
Its comprehensive coverage makes this volume a valuable resource for researchers in cell and neurophysiology, as well as graduate students of the neurosciences.


Caracteristici

Broadens readers’ understanding of the clinical importance of the choroid plexus as the main source of cerebrospinal fluid Shares insights into drug development strategies targeting the blood / cerebrospinal fluid barrier using choroid plexus epithelial cells Emphasizes the correlation between the production and composition of CSF and the maintenance of normal brain function