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Scalable Green Chemistry: Case Studies from the Pharmaceutical Industry de Stefan Koenig

Scalable Green Chemistry: Case Studies from the Pharmaceutical Industry

Editat de Stefan Koenig
en Limba Engleză Hardback – 11 sep 2013
Packed with real-world examples, this book illustrates the 12 principles of green chemistry. These diverse case studies demonstrate to scientists and students that beyond the theory, the challenges of green chemistry in pharmaceutical discovery and development remain an ongoing endeavor. By informing and welcoming additional practitioners to this mission, the negative environmental impact of pharmaceutical products will continue to be minimized. Green chemistry is the methodology by which chemical production in this industry can become more efficient, adding environmental stewardship to the noble mission of treating human disease.
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Specificații

ISBN-13: 9789814316491
ISBN-10: 9814316490
Pagini: 388
Ilustrații: 187 b/w images
Dimensiuni: 152 x 229 x 28 mm
Greutate: 0.66 kg
Ediția:1
Editura: Jenny Stanford Publishing
Colecția Jenny Stanford Publishing

Public țintă

Academic and Postgraduate

Recenzii

"At last! A book which provides a discussion of green chemistry from a process chemistry/engineering viewpoint. The case studies on individual pharmaceuticals in the various chapters are supplemented by a great general introductory chapter and a final concluding chapter by the editor."
--Dr. Trevor Laird, Editor, Organic Process Research & Development
"This monograph is a tutorial featuring not only an impressive overview of the virtues of green chemistry, but also real-world cases that illustrate how this emerging field can be applied within the pharma arena to great economic, as well as environmental, advantage."
--Prof. Bruce H. Lipshutz, University of California, Santa Barbara, USA
"This thirteen-chapter book summarizes the most recent green chemistry and engineering achievements in the pharmaceutical industry. It provides good examples that illustrate the concept of green-by-design, the practice of green metrics, and the advancement of green technologies in drug design, development and production."
--Prof. Wei Zhang, University of Massachusetts Boston, USA

"Scalable Green Chemistry represents an important and timely contribution to the armamentarium of the pharmaceutical green chemist. This book’s case studies, contributed by well-known and highly respected authors from this field, will be catalysts for the progression and broader adoption of a more sustainable way to do drug synthesis and manufacture."
--Dr. Berkeley W. Cue, Jr., BWC Pharma Consulting LLC, USA

"This timely book illustrates the application of green chemistry principles to several prominent cases in greener pharmaceutical manufacturing. It showcases excellent examples of the impact of green chemistry on the pharmaceutical industry."
--Prof. Chao-Jun Li, McGill University, Canada

Cuprins

Preface, Acknowledgments, 1 Introduction to Green Pharmaceutical Science: Fact, Fiction, and Future, 2 Green Chemistry in Drug Development, 3 Development of Green-by-Design, Practical Biocatalytic Processes, 4 Application of Green Metrics to Scalable Industrial Synthesis Plans: Approaches to Oseltamivir Phosphate (Tamiflu R _), 5 The Road to Becoming Green: Process Development of AR-A2, an Active Pharmaceutical Ingredient with Antidepressant Activity, 6 Improved and Greener Process for Pioglitazone and Its Pharmaceutically Acceptable Salts, 7 The Development of a Convergent Green Synthesis of Linezolid, an Oxazolidinone Antibacterial Agent, 8 Development of a Nonaqueous Process for the Synthesis of 3-Amino-pentan-1,5-diol, 9 Development of a Robust, Environmentally Responsible Process for the Manufacture of Tofacitinib Citrate, 10 Selective Nitration under cGMP Conditions, 11 Going Green Using Combined Real-Time Analytics and Process Automation, 12 Approaches to the Scale-Up of Organic Chemistry Using Microwave Heating, 13 Challenges Faced and Future Directions, Index

Descriere

Packed with real-world examples, this book illustrates the 12 principles of green chemistry. These diverse case studies demonstrate to scientists and students that beyond the theory, the challenges of green chemistry in pharmaceutical discovery and development remain an ongoing endeavor. By informing and welcoming additional practitioners to this mission, the negative environmental impact of pharmaceutical products will continue to be minimized. Green chemistry is the methodology by which chemical production in this industry can become more efficient, adding environmental stewardship to the noble mission of treating human disease.