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Sparking Signals: Kinases as Molecular Signaltransducers and Pharmacological Drug Targets in Inflammation: Ernst Schering Foundation Symposium Proceedings, cartea 2007/3

Editat de Gottfried Baier, Burkhart Schraven, Ulrich Zügel, Arne Bonin
en Limba Engleză Hardback – 11 apr 2008
Protein phosphorylation is an essential post-translational modification that modulates cell–cell communication. Substrate phosphorylation by protein kinases controls intracellular signal transduction pathways that mediate cell proliferation, migration, differentiation, and metabolism. The importance of the protein kinase family is underscored by numerous disease states that arise due to dysregulation of kinase activity. Recent progress in understanding the molecular regulation of kinases has led to the development of new therapeutics based on the inhibition of kinase activity. Inhibitors that target protein kinases have proven efficacious in clinical settings and their continued development is the current focus of many drug discovery groups.
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Specificații

ISBN-13: 9783540735007
ISBN-10: 3540735003
Pagini: 204
Ilustrații: XIV, 187 p.
Dimensiuni: 155 x 235 x 17 mm
Greutate: 0.39 kg
Ediția:2008
Editura: Springer Berlin, Heidelberg
Colecția Springer
Seria Ernst Schering Foundation Symposium Proceedings

Locul publicării:Berlin, Heidelberg, Germany

Public țintă

Professional/practitioner

Cuprins

Proteomics-Based Strategies in Kinase Drug Discovery.- PKC Isotype Functions in T Lymphocytes.- Migration, Cell–Cell Interaction and Adhesion in the Immune System.- Molecular Mechanisms that Control Leukocyte Extravasation Through Endothelial Cell Contacts.- Fragment-Based Drug Discovery Using Rational Design.- Systems Biology of T Cell Activation.- Solving the IRAK-4 Enigma: Application of Kinase-Dead Knock-In Mice.- Sensing, Presenting, and Regulating PAMPS.- The Role of Diacylglycerol Kinases in T Cell Anergy.

Caracteristici

Internationally well known experts presented their most recent findings on the fast developing kinase field Outstanding interest for basic researchers and pharmaceutical industry