Stereochemical Aspects of Drug Action and Disposition: Handbook of Experimental Pharmacology, cartea 153

Chemical Aspects.- 1 Recent Developments in Asymmetric Organic Synthesis: Principles and Examples.- 2 Stereoselective Separations: Recent Advances in Capillary Electrophoresis and High-Performance Liquid Chromatography.- 3 Stereochemical Issues in Bioactive Natural Products.- 4 Drug Racemization and Its Significance in Pharmaceutical Research.- 5 Physical Properties and Crystal Structures of Chiral Drugs.- Experimental Pharmacology.- 6 Chiral Recognition in Biochemical Pharmacology: An Overview.- 7 Enantioselectivity in Drug-Receptor Interactions.- 8 Mechanisms of Stereoselective Binding to Functional Proteins.- 9 Stereoselective Drug-Channel Interactions.- 10 Stereoselective Bioactivation and Bioinactivation — Toxicological Aspects.- Drug Absorption, Distribution, Metabolism, Elimination.- 11 Intestinal Drug Transport: Stereochemical Aspects.- 12 Enantioselective Plasma and Tissue Binding.- 13 Stereoselective Drug Metabolism and Drug Interactions.- 14 Metabolic Chiral Inversion of 2-Arylpropionic Acids.- 15 Stereoselective Renal Elimination.- Implications for Drug Development and Therapy.- 16 Regulatory Requirements for the Development of Chirally Active Drugs.- 17 Improving Clinical Risk/Benefit Through Stereochemistry.