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Stress-Inducible Cellular Responses: Experientia Supplementum, cartea 77

Editat de U. Feige, R.I. Morimoto, Barbara Polla
en Limba Engleză Paperback – 17 sep 2011

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Specificații

ISBN-13: 9783034899017
ISBN-10: 3034899017
Pagini: 512
Ilustrații: XII, 495 p.
Dimensiuni: 170 x 244 x 27 mm
Greutate: 0.81 kg
Ediția:Softcover reprint of the original 1st ed. 1996
Editura: Birkhäuser Basel
Colecția Birkhäuser
Seria Experientia Supplementum

Locul publicării:Basel, Switzerland

Public țintă

Research

Cuprins

I: Functions of stress proteins in unstressed cells.- Normal protein folding machinery.- Roles for hsp70 in protein translocation across membranes of organelles.- Protein folding and assembly in the endoplasmic reticulum.- Involvement of molecular chaperones in intracellular protein breakdown.- Molecular chaperoning of steroid hormone receptors.- Protein disulfide isomerase: A multifunctional protein of the endoplasmic reticulum.- II: Regulation of inducible stress responses.- Sensing stress and responding to stress.- The transcriptional regulation of heat shock genes: A plethora of heat shock factors and regulatory conditions.- Transcriptional regulation of stress-inducible genes in procaryotes.- The impact of oxidative stress on eukaryotic iron metabolism.- Heat-shock induced protein modifications and modulation of enzyme activities.- SOS response as an adaptive response to DNA damage in prokaryotes.- III: Cellular responses to specific stresses.- Transcriptional regulators of oxidative stress-inducible genes in prokaryotes and eukaryotes.- UV activation of mammalian stress proteins.- Signaling events controlling the molecular response to genotoxic stress.- Mammalian DNA repair responses and genomic instability.- Toxic metal-responsive gene transcription.- Tumor necrosis factor and lymphotoxin: Protection against oxidative stress through induction of MnSOD.- IV: Paradigms for complex stress responses.- Viral infection.- Infection, autoimmunity and autoimmune disease.- Stress proteins in inflammation.- Attenuated heat shock transcriptional response in aging: Molecular mechanism and implication in the biology of aging.- V: Applications of stress responses in toxicology and pharmacology.- Stress proteins as molecular biomarkers for environmental toxicology.- Thermotolerance and heat shock proteins: Possible involvement of Ku autoantigen in regulating HSP70 expression.- Heat shock proteins as immunological carriers and vaccines.- Regulation of thermotolerance and ischemic tolerance.- Future applications.- Outlook.