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Structural and Mechanistic Enzymology: Bringing Together Experiments and Computing: Advances in Protein Chemistry and Structural Biology, cartea 87

Christo Christov, Tatyana Karabencheva-Christova
en Limba Engleză Hardback – 7 iul 2012
Both strategies for investigation (computational and experimental) in structural and mechanistic Enzymology have developed to some extent independently. However, over the last few years a trend has emerged for strengthening their integration. This combination not only brings together computations and experiments focused on the same enzymatic problems, but also provides complementary insights into the investigated properties and has a powerful synergy effect. This thematic volume of Advances in Protein Chemistry and Structural Biology focuses on the recent success in structural and mechanistic enzymology and has its main emphasis on explaining the enzyme phenomena by using both the experimental and computational approaches. The selected contributions demonstrate how the application of a variety of experimental techniques and modeling methods helps further the understanding of enzyme dynamics, mechanism, inhibition, and drug design.


  • Focuses on the recent success in structural and mechanistic enzymology
  • Has its main emphasis on explaining the enzyme phenomena by using both the experimental and computational approaches
  • Demonstrates how the application of a variety of experimental techniques and modeling methods helps further the understanding of enzyme dynamics, mechanism, inhibition, and drug design
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Specificații

ISBN-13: 9780123983121
ISBN-10: 0123983126
Pagini: 472
Dimensiuni: 152 x 229 x 25 mm
Greutate: 0.79 kg
Ediția:Revised
Editura: ELSEVIER SCIENCE
Seria Advances in Protein Chemistry and Structural Biology


Public țintă

Biochemists, biophysicists, cell biologists, protein chemists, structural geneticists, and structural biologists

Cuprins

    1. Structural and Computational Enzymology: Bringing Experiments and Computations Together Tatyana Karabencheva and Christo Christov
    2. Structural and Functional Analysis of Proteins by High-Speed Atomic Force Microscopy Arivazhagan Rajendran, Masayuki Endo and Hiroshi Sugiyama
    3. Reaction Intermediates Discovered in Crystal Structures of Enzymes Irene T. Weber, Johnson Agniswamy, Guoxing Fu, Chen-Hsiang Shen and Robert W. Harrison
    4. Structural, Functional and Mutagenesis Studies of UDP-Glycosyltransferases Vatsala Malik and Gary W Black
    5. Vipoxin and its Components: Structure – Function Relationship S. D. Petrova, V. N. Atanasov and K. Balashev
    6. Experimental and Theoretical Studies of Enzyme-Catalyzed Hydrogen Transfer Reactions Zhen Wang, Daniel Roston and Amnon Kohen
    7. Protein Flexibility and Enzymatic Catalysis M. Kokkinidis, N. M. Glykos and V. E. Fadouloglou
    8. Molecular Modeling of Inhibitors of Human DNA Methyltransferase with a Crystal Structure: Discovery of a Novel DNMT1 Inhibitor Jakyung Yoo, Joo Hee Kim, Keith D. Robertson and José L. Medina-Franco
    9. In Silico Strategies Towards Enzyme Function and Dynamics Sílvia G. Estácio
    10. Dynamic Simulations as a Complement to Experimental Studies of Enzyme Mechanisms Andrew Christofferon, Lifeng Zhao and Qiang Pei
    11. The Increasing Role of QM/MM in Drug Discovery Alessio Lodola and Marco De Vivo
    12. Probing Allostery and Binding Cooperativity of the Catalytic Subunit of Protein Kinase A by NMR Spectroscopy and Molecular Dynamics Simulations Larry R. Masterson, Alessandro Cembran, Lei Shi and Gianluigi Veglia
    13. Using a Combination of Computational and Experimental Techniques to Understand the Molecular Basis for Protein Allostery

      Wanting Jiao and Emily J. Parker