Synthesis and Characterization of Glycosides
Autor Marco Brito-Ariasen Limba Engleză Paperback – 24 noi 2010
This third edition is a comprehensive and extended study about the best known approaches for preparing the main types of glycosides, covering the classic and more recent glycosylation reactions used for preparing simple and challenging glycosides currently used as potent antiviral and antineoplastic drugs, or fluorogenic substrates used for enzymatic detection in cell biology. Besides, this new edition provides more examples of the glycosidic methodologies followed for preparing complex glycoconjugates such as glycoproteins and glycosphingolipids and gangliosides used as adjuvants or as synthetic vaccines candidates.
Also, additional mechanistic evidence is presented for better understanding of the glycosylation reaction, trying to identify the variables mainly depending on protecting and leaving groups, as well as catalyst and reaction condition which altogether directs the anomeric stereo control.
A chapter on the glycoside hydrolysis is included in view ofthe increasing interest in the use of biomass as a natural and renewable source for obtaining important intermediates or products used in food or valuable materials. The author includes information in the characterization of glycosides section with the aim of giving additional tools for the structural assignment through NMR, X-Ray and mass spectra techniques.
Also, additional mechanistic evidence is presented for better understanding of the glycosylation reaction, trying to identify the variables mainly depending on protecting and leaving groups, as well as catalyst and reaction condition which altogether directs the anomeric stereo control.
A chapter on the glycoside hydrolysis is included in view ofthe increasing interest in the use of biomass as a natural and renewable source for obtaining important intermediates or products used in food or valuable materials. The author includes information in the characterization of glycosides section with the aim of giving additional tools for the structural assignment through NMR, X-Ray and mass spectra techniques.
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Specificații
ISBN-13: 9781441938770
ISBN-10: 144193877X
Pagini: 364
Ilustrații: XII, 352 p. 389 illus.
Dimensiuni: 155 x 235 x 19 mm
Greutate: 0.51 kg
Ediția:Softcover reprint of hardcover 1st ed. 2007
Editura: Springer Us
Colecția Springer
Locul publicării:New York, NY, United States
ISBN-10: 144193877X
Pagini: 364
Ilustrații: XII, 352 p. 389 illus.
Dimensiuni: 155 x 235 x 19 mm
Greutate: 0.51 kg
Ediția:Softcover reprint of hardcover 1st ed. 2007
Editura: Springer Us
Colecția Springer
Locul publicării:New York, NY, United States
Public țintă
Professional/practitionerCuprins
Glycosides, Synthesis, and Characterization.- O-Glycoside Formation.- N-Glycosides.- Nucleoside Mimetics.- C-Glycosides.- Glycoconjugates.- Hydrolysis of Glycosides.- Nuclear Magnetic Resonance of Glycosides.- X-Ray Diffraction of Glycosides.- Mass Spectrometry of Glycosides.
Recenzii
From the reviews:
"Brito-Arias … provides an overview of the structures and synthetic preparations of O-, N-, and C-glycosides, as well as discussion of the conformational features and biological function of selected examples. … The organization of the book provides a ready resource for researchers seeking information. Indeed, the references to published synthetic methodology or analytical data included at the end of each chapter will be useful for researchers seeking additional information or details on a specific topic. … Summing Up: Recommended. Graduate students through professionals." (P. W. Baures, CHOICE, Vol. 44 (11), July, 2007)
"Brito-Arias … provides an overview of the structures and synthetic preparations of O-, N-, and C-glycosides, as well as discussion of the conformational features and biological function of selected examples. … The organization of the book provides a ready resource for researchers seeking information. Indeed, the references to published synthetic methodology or analytical data included at the end of each chapter will be useful for researchers seeking additional information or details on a specific topic. … Summing Up: Recommended. Graduate students through professionals." (P. W. Baures, CHOICE, Vol. 44 (11), July, 2007)
Caracteristici
Wide range of glycosides discussed Presents synthetic pathways of challenging glycosides Detailed treatment of structural characterization Includes supplementary material: sn.pub/extras
Notă biografică
Marco Brito-Arias is at the National Polytechnic Institute in Mexico.
Textul de pe ultima copertă
This third edition is a comprehensive and extended study about the best known approaches for preparing the main types of glycosides, covering the classic and more recent glycosylation reactions used for preparing simple and challenging glycosides currently used as potent antiviral and antineoplastic drugs, or fluorogenic substrates used for enzymatic detection in cell biology. Besides, this new edition provides more examples of the glycosidic methodologies followed for preparing complex glycoconjugates such as glycoproteins and glycosphingolipids and gangliosides used as adjuvants or as synthetic vaccines candidates.
Also, additional mechanistic evidence is presented for better understanding of the glycosylation reaction, trying to identify the variables mainly depending on protecting and leaving groups, as well as catalyst and reaction condition which altogether directs the anomeric stereo control.
A chapter on the glycoside hydrolysis is included in view of the increasing interest in the use of biomass as a natural and renewable source for obtaining important intermediates or products used in food or valuable materials. The author includes information in the characterization of glycosides section with the aim of giving additional tools for the structural assignment through NMR, X-Ray and mass spectra techniques.
A chapter on the glycoside hydrolysis is included in view of the increasing interest in the use of biomass as a natural and renewable source for obtaining important intermediates or products used in food or valuable materials. The author includes information in the characterization of glycosides section with the aim of giving additional tools for the structural assignment through NMR, X-Ray and mass spectra techniques.