In this issue of Dental Clinics, guest editor Dr. Davis Thomas brings his considerable expertise to the topic of Systemic Factors Affecting Prognosis in Dentistry. Many health conditions and diseases can affect oral health, either systemically or due to physical inability to maintain appropriate oral hygiene. Conditions such as chronic pain, stress, or infections present a number of symptoms that may provide challenges to the dentist. This issue takes a holistic approach to treatment planning for systemic factors, with articles on implants, periodontal therapy, medications, genetics, orthodontics, and psychological issues.