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The Cannabinoid Receptors de Patricia H. Reggio

The Cannabinoid Receptors: The Receptors

Editat de Patricia H. Reggio
en Limba Engleză Hardback – 18 dec 2008
As research has progressed, the cannabinoid CB 1 and CB 2 receptors have expanded significantly in importance within the neuroscience mainstream. In The Cannabinoid Receptors, leading experts introduce newcomers to the cannabinoid field with chapters covering cannabinoid ligand synthesis and structure activity relationships, the molecular pharmacology of the cannabinoid receptors and the endocannabinoid system, and ultimately, the whole animal pharmacology and therapeutic applications for cannabinoid drugs. Adding to those key topics, the book also examines the current direction of the field with chapters on new putative cannabinoid receptors and challenges for future research. As a part of The Receptors ™ series, this volume highlights its receptor with the most thorough, focused and essential information available.
Comprehensive and cutting-edge, The Cannabinoid Receptors serves as an ideal guidebook to what continues to be a fascinating and vital field.
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Specificații

ISBN-13: 9781588297129
ISBN-10: 1588297128
Pagini: 420
Ilustrații: XIV, 402 p. 65 illus., 6 illus. in color.
Dimensiuni: 155 x 235 x 28 mm
Greutate: 0.73 kg
Ediția:2009
Editura: Humana Press Inc.
Colecția Humana
Seria The Receptors

Locul publicării:Totowa, NJ, United States

Public țintă

Research

Cuprins

Cannabinoid Receptor Ligands and Structure-Activity Relationships.- Structure–Activity Relationships of Classical Cannabinoids.- Endocannabinoids and Their Synthetic Analogs.- Cannabimimetic Indoles, Pyrroles, and Indenes: Structure–Activity Relationships and Receptor Interactions.- Structure–Activity Relationships and Conformational Freedom of CB1 Receptor Antagonists and Inverse Agonists.- Cannabinoid Receptor Biology.- Cannabinoid Receptor Genetics and Evolution.- Cannabinoid Receptor Molecular Pharmacology.- Cannabinoid Receptor Signal Transduction Pathways.- Cannabinoid Agonist and Inverse Agonist Regulation of G Protein Coupling.- Molecular Biology of Cannabinoid Receptors: Mutational Analyses of the CB Receptors.- Models of Cannabinoid Inverse Agonism, Neutral Antagonism, and Agonism: Tools for Rational Drug Design.- The Endocannabinoid System.- Endocannabinoids as Modulators of Synaptic Signaling.- New Insights into the Endocannabinoid System by Using Cannabinoid Receptor Knockout Mice.- Cannabinoid Receptor Pharmacology.- Preclinical Pharmacological and Brain Bioassay Systems for CB1 Cannabinoid Receptors.- Therapeutic Applications for Agents that Act at CB1 and CB2 Receptors.

Recenzii

From the reviews:
"The Cannabinoid Receptors arrives as the 18 member of The Receptors series and offers the reader a sophisticated overview of the structure–activity relationship advances realized in the design of cannabinoid (CB) based drugs. The book presents CB receptors in five parts … . The chapters are thoroughly referenced, including the latest primary literature, and the index serves well. … The intended audience includes industry/academic medicinal chemists and pharmacologists who are new to the CB field." (Kennerly S. Patrick, Journal of Medicinal Chemistry, September, 2009)
“This book is great if you want a lot of information about the cannabinoid receptors in one place; from evolution to molecular biology and medicinal chemistry, it is all here. … This is a nicely written piece presenting molecular modelling analyses of the cannabinoid ligands. … This book is intended for newcomers to the cannabinoid field … . it is a good book to have.” (David Selwood, ChemMedChem, Issue 4, 2009)

Textul de pe ultima copertă

As research has progressed, the cannabinoid CB 1 and CB 2 receptors have expanded significantly in importance within the neuroscience mainstream. In The Cannabinoid Receptors, leading experts introduce newcomers to the cannabinoid field with chapters covering cannabinoid ligand synthesis and structure activity relationships, the molecular pharmacology of the cannabinoid receptors and the endocannabinoid system, and ultimately, the whole animal pharmacology and therapeutic applications for cannabinoid drugs. Adding to those key topics, the book also examines the current direction of the field with chapters on new putative cannabinoid receptors and challenges for future research. As a part of The Receptors ™ series, this volume highlights its receptor with the most thorough, focused and essential information available.
Comprehensive and cutting-edge, The Cannabinoid Receptors serves as an ideal guidebook to what continues to be a fascinating and vital field.

Caracteristici

Offers a comprehensive look at cannabinoid structure activity relationships for all structural classes of cannabinoid agonists, including endogenous cannabinoids as well as cannabinoid antagonists/inverse agonists Provides a thorough overview of the cannabinoid receptor field including the genetics and evolution of the cannabinoid system, as well as the molecular biology and structure/function of the cannabinoid receptors Discusses the many therapeutic opportunities provided by the endocannabinoid system, including treatments for metabolic syndrome and immune system disorders