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The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics de Bryan L. Roth

The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics: The Receptors

Editat de Bryan L. Roth
en Limba Engleză Hardback – iun 2006
A comprehensive, state-of-the-art review of our current understanding of the molecular and structural biology of 5-HT receptors and their potential use for drug discovery. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.
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Specificații

ISBN-13: 9781588295682
ISBN-10: 1588295680
Pagini: 644
Ilustrații: XVIII, 618 p. 82 illus., 5 illus. in color.
Dimensiuni: 152 x 229 x 45 mm
Greutate: 1 kg
Ediția:2006
Editura: Humana Press Inc.
Colecția Humana
Seria The Receptors

Locul publicării:Totowa, NJ, United States

Public țintă

Research

Cuprins

Molecular Biology and Genomic Organization of G Protein-Coupled Serotonin Receptors.- Structure and Function Reveal Insights in the Pharmacology of 5-HT Receptor Subtypes.- Polymorphic and Posttranscriptional Modifications of 5-HT Receptor Structure.- Strategies for the Development of Selective Serotonergic Agents.- 5-HT Receptor Signal Transduction Pathways.- Agonist-Directed Trafficking of 5-HT Receptor-Mediated Signal Transduction.- Identification of 5-HT2 and 5-HT4 Receptor-Interacting Proteins.- 5-HT Receptor-Associated Proteins (FRAPs).- Cellular and Subcellular Localization of Serotonin Receptors in the Central Nervous System.- Chemical Neuroanatomy of 5-HT Receptor Subtypes in the Mammalian Brain.- Modulation of the Neuronal Activity and Neurotransmitter Release by 5-HT1A and 5-HT1B/1D Receptors.- Electrophysiology of 5-HT2A Receptors and Relevance for Hallucinogen and Atypical Antipsychotic Drug Actions.- The Emergence of 5-HT2B Receptors as Targets to Avoid in Designing and Refining Pharmaceuticals.- The 5-HT3 Receptor.- 5-HT3 and 5-HT4 Receptors as Targets for Drug Discovery for Dementia.- Electrophysiological Properties of G?s-Coupled 5-HT Receptors (5-HT4, 5-HT6, 5-HT7).- 5-HT6 Receptors as Targets for the Treatment of Cognitive Deficits in Schizophrenia.- 5-HT7 Receptors as Favorable Pharmacological Targets for Drug Discovery.- Serotonin System Gene Knockouts.- Effects of Serotonin-Related Gene Deletion on Measures of Anxiety, Depression, and Neurotransmission.

Recenzii

From the reviews:
"This is a compilation of reviews regarding various aspects of serotonin receptor structure and function. … As a set of reviews, the book can be read by a broad scientific audience. Material of interest to senior scientists and research fellows is present. … Investigators wishing an up-to-date review of this field will find this book valuable. Those with selected interest, whether evolutionary or structural, will also find useful material. … is a good, comprehensive set of reviews. … overall, it is a valuable book." (Eugene A Davidson, Doody’s Review Service, February, 2007)

Textul de pe ultima copertă

The recent cloning and identification of a large number of serotonin (5-HT) receptors-a major family of therapeutic targets-holds out the possibility of developing novel, subtype-selective 5-HT receptor agonists and antagonists for use as psychiatric, cardiovascular, and neurological medications. In The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics, leading experts comprehensively examine our current understanding of the molecular and structural biology of 5-HT receptors and their pharmacological use. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.
Comprehensive and state of the art, The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics provides an illuminating "snapshot" of the 5-HT receptor field today and prospects for the future, taking it from the genomic to a systems level of understanding.

Caracteristici

Includes supplementary material: sn.pub/extras