The Pharmacology of Functional, Biochemical, and Recombinant Receptor Systems: Handbook of Experimental Pharmacology, cartea 148
Editat de T. Kenakin, J. A. Angusen Limba Engleză Paperback – 24 oct 2012
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Specificații
ISBN-13: 9783642630286
ISBN-10: 3642630286
Pagini: 472
Ilustrații: XX, 448 p. 132 illus., 1 illus. in color.
Dimensiuni: 155 x 235 x 32 mm
Greutate: 0.65 kg
Ediția:Softcover reprint of the original 1st ed. 2000
Editura: Springer Berlin, Heidelberg
Colecția Springer
Seria Handbook of Experimental Pharmacology
Locul publicării:Berlin, Heidelberg, Germany
ISBN-10: 3642630286
Pagini: 472
Ilustrații: XX, 448 p. 132 illus., 1 illus. in color.
Dimensiuni: 155 x 235 x 32 mm
Greutate: 0.65 kg
Ediția:Softcover reprint of the original 1st ed. 2000
Editura: Springer Berlin, Heidelberg
Colecția Springer
Seria Handbook of Experimental Pharmacology
Locul publicării:Berlin, Heidelberg, Germany
Public țintă
ResearchCuprins
Introduction: Bioassays — Past Uses and Future Potential.- Section I: Classical Pharmacology and Isolated Tissue Systems.- 1 Human Vascular Receptors in Disease: Pharmacodynamic Analyses in Isolated Tissue.- 2 Problems in Assigning Mechanisms: Reconciling the Molecular and Functional Pathways in ?-Adrenoceptor-Mediated Vasoconstriction.- 3 Gs Protein-Coupled Receptors in Human Heart.- Section II: New Theoretical Concepts and Molecular Mechanisms of Receptor Function.- 4 Kinetic Modeling Approaches to Understanding Ligand Efficacy.- 5 The Evolution of Drug-Receptor Models: The Cubic Ternary-Complex Model for G Protein-Coupled Receptors.- 6 Inverse Agonism.- 7 Efficacy: Molecular Mechanisms and Operational Methods of Measurement. A New Algorithm for the Prediction of Side Effects.- 8 A Look at Receptor Efficacy. From the Signalling Network of the Cell to the Intramolecular Motion of the Receptor.- 9 Mechanisms of Non-Competitive Antagonism and Co-Agonism.- 10 Mechanisms of Receptor Activation and the Relationship to Receptor Structure.- Section III: New Technologies for the Study of Drug Receptor Interaction.- 11 The Assembly of Recombinant Signalling Systems and Their Use in Investigating Signaling Dynamics.- 12 Insect Cell Systems to Study the Communication of Mammalian Receptors and G Proteins.- 13 Altering the Relative Stoichiometry of Receptors, G Proteins and Effectors: Effects on Agonist Function.- 14 The Study of Drug-Receptor Interaction Using Reporter Gene Systems in Mammalian Cells.- 15 Melanophore Recombinant Receptor Systems.
Caracteristici
Includes supplementary material: sn.pub/extras