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Thymic Development and Selection of T Lymphocytes: Current Topics in Microbiology and Immunology, cartea 373

Editat de Thomas Boehm, Yousuke Takahama
en Limba Engleză Hardback – 19 noi 2013
The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.
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Specificații

ISBN-13: 9783642402517
ISBN-10: 3642402518
Pagini: 130
Ilustrații: VII, 132 p. 11 illus., 9 illus. in color.
Dimensiuni: 155 x 235 x 15 mm
Greutate: 0.34 kg
Ediția:2014
Editura: Springer Berlin, Heidelberg
Colecția Springer
Seria Current Topics in Microbiology and Immunology

Locul publicării:Berlin, Heidelberg, Germany

Public țintă

Research

Cuprins

Development and Function of Cortical Thymic Epithelial Cells.- Mechanisms of Thymus Medulla Development And Function.- Self-peptides in TCR Repertoire Selection and Peripheral T Cell Function.-  Central Tolerance Induction.- Trafficking to the Thymus.- The CD4/CD8 Lineages: Central Decisions and Peripheral Modifications for T Lymphocytes.

Caracteristici

Written by leading experts in the field Addresses key aspects of the process of thymopoiesis Offers perspectives for understanding immunodeficiency and autoimmune diseases Includes supplementary material: sn.pub/extras