Tumor Models in Cancer Research de Beverly A. Teicher

Tumor Models in Cancer Research: Cancer Drug Discovery and Development

Beverly A. Teicher

The past 6 years since the first edition of this book have seen great progress in the development of genetically engineered mouse (GEM) models of cancer. These models are finding an important role in furthering our understanding of the biology of malignant disease. A comfortable position for GEM models in the routine conduct of screening for potential new therapeutics is coming more slowly but is coming. Increasing numbers of genetically engineered mice are available, some with conditional activation of oncogenes, some with multiple genetic changes providing mouse models that are moving closer to the human disease.

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Paperback (1)	1432^.17 lei 6-8 săpt.
Humana Press Inc. – 28 noi 2014	1432^.17 lei 6-8 săpt.
Hardback (1)	1452^.28 lei 6-8 săpt.
Humana Press Inc. – 2 dec 2010	1452^.28 lei 6-8 săpt.

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Paperback (1)

1432^.17 lei 6-8 săpt.

Humana Press Inc. – 28 noi 2014

1432^.17 lei 6-8 săpt.

Hardback (1)

1452^.28 lei 6-8 săpt.

Humana Press Inc. – 2 dec 2010

1452^.28 lei 6-8 săpt.

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Notă biografică

Dr. Beverly A. Teicher is Senior Scientific Director in Cancer Research at Genzyme Molecular Oncology and Genzyme Corporation, Framingham, Massachusetts. She has authored or co-authored more than 400 scientific publications, has edited five books, senior editor for the journal Clinical Cancer Research and is series editor for the Cancer Drug Discovery and Development book series.

Textul de pe ultima copertă

Beverly A. Teicher and a panel of leading experts comprehensively describe the state-of-the-art in animal tumor model research. This volume updates and extends the comprehensive presentations in the first edition. The wide array of models detailed form the basis for the selection of compounds and treatments that go into clinical testing of patients, and include syngeneic models, human tumor xenograft models, orthotopic models, metastatic models, and genetically engineered mouse models. Synthesizing many years experience with all the major in vivo models currently available for the study of malignant disease, Tumor Models in Cancer Research 2nd edition, provides preclinical and clinical cancer researchers alike with a comprehensive guide to the selection of these models, their effective use, and the optimal interpretation of their results.

Caracteristici

Comprehensively describes in a new, updated edition the state-of-the-art in animal tumor model research. Includes syngeneic models, human tumor xenograft models, orthotopic models, metastatic models, transgenic models, and gene knockout models. Tumor Models in Cancer Research provides preclinical and clinical cancer researchers alike with a comprehensive guide to the selection of these models, their effective use, and the optimal interpretation of their results.