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Targets for Cancer Chemotherapy: Transcription Factors and Other Nuclear Proteins: Cancer Drug Discovery and Development

Editat de Nicholas B. La Thangue, Lasantha R. Bandara
en Limba Engleză Paperback – 19 noi 2010
In Targets for Cancer Chemotherapy: Transcription Factors and Other Nuclear Proteins, a panel of leading basic researchers, pharmaceutical scientists, and clinical oncologists explain in detail the therapeutically-relevant protein targets that contribute to cancer pathology and spell out their implications for cancer drug discovery and clinical application. The authors identify and illuminate selected transcription factor oncoproteins and tumor suppressors, together with nuclear proteins that are central to the phenotype of the tumor cell involved in chromatin control. The emphasis is on new targets and approaches to cancer treatment derived from the cancer cell cycle, gene control targets, and angiogenesis.
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Specificații

ISBN-13: 9781617372636
ISBN-10: 1617372633
Pagini: 368
Ilustrații: XII, 352 p.
Dimensiuni: 152 x 229 x 19 mm
Greutate: 0.64 kg
Ediția:Softcover reprint of hardcover 1st ed. 2002
Editura: Humana Press Inc.
Colecția Humana
Seria Cancer Drug Discovery and Development

Locul publicării:Totowa, NJ, United States

Public țintă

Professional/practitioner

Cuprins

Cancer Chemotherapy Based on E2F and the Retinoblastoma Pathway. Myc Oncoproteins as Targets for Therapeutic Intervention in Tumorigenesis. The AP-1 Family of Transcription Factors: Structure, Regulation, and Functional Analysis in Mice. Hypoxia-Induced Factor-1 as a Target for Anticancer Therapy. Nuclear b-Catenin Signaling as a Target for Anticancer Drug Development Histone Acetyltransferases as Potential Targets for Cancer Therapies. Histone Deacetylases. Cyclin-Dependent Kinases and Their Small-Molecule Inhibitors in Cancer Therapy. Mitogen-Activated Protein Kinase Cascades as Therapeutic Targets in Cancer. Mdm2 and ARF. The Breast Cancer Susceptibility Genes, BRCA1 and BRCA2. Human Papillomavirus Targets for Therapeutic Intervention. Apoptin as an Anticancer Therapy. E2F and Cancer Chemotherapy. Hypoxic Signaling Pathways as Targets for Anticancer Therapy. Androgen Receptor and Estrogen Receptors. Index.

Recenzii

'This book will be of interest to drug development professionals and oncology researchers. Specific chapters make good reviews for clinicians interested in emerging therapies and may also be useful for students." - Today's Life Science

"The book is included in the successful series of publications "Cancer Drug Discovery and Development" form Humana Press. It will be of interest both to clinicians and to laboratory cancer researchers, as well as to people who are interested in recent achievements in molecular oncology, which gives new hope for better treatment of caner patients." - Neoplasma

Textul de pe ultima copertă

Recent scientific discoveries concerning therapeutically relevant protein targets that contribute to cancer pathology have opened new possibilities in the search for effective cancer treatments. In Targets for Cancer Chemotherapy: Transcription Factors and Other Nuclear Proteins, a panel of leading basic researchers, pharmaceutical scientists, and clinical oncologists provide, in an easy-to-understand format, a detailed account of these latest research developments and spell out their implications for cancer drug discovery and clinical application. The authors identify and illuminate selected transcription factor oncoproteins and tumor suppressors, together with nuclear proteins that are central to the phenotype of the tumor cell and including recently elucidated enzymes involved with chromatin control. The emphasis is on new targets and approaches to cancer treatment derived from the cancer cell cycle, gene and chromatin control targets, and angiogenesis. Among the targets considered are E2F, Myc oncoproteins, hypoxic signaling pathways, Mdm2 and ARF, the AP-1 family of transcription factors, histone deacetylase, histone acetyl transferase, apoptin, and nuclear ß-catenin signaling.
Up-to-date and insightful, Targets for Cancer Chemotherapy: Transcription Factors and Other Nuclear Proteins shows clearly how our new understanding of critical molecular targets in cancer cells can be applied to cancer drug discovery to provide new drug discovery platforms both for future development and for new target-based medicines for cancer patients.

Caracteristici

Includes supplementary material: sn.pub/extras