Cantitate/Preț
Produs

Valproate: Milestones in Drug Therapy

Editat de Wolfgang Löscher
en Limba Engleză Paperback – 13 oct 2012
Since the fortuitous discovery of its anticonvulsant activIty in 1962, valproate has established itself worldwide as a major antiepileptic drug against several types of epileptic seizures. Clinical experience with valpro­ ate has continued to grow in recent years, including use of valproate for diseases other than epilepsy, for example in bipolar disorders and migraine. In this volume on valproate emphasis is placed on the scientific back­ ground leading to the discovery of val pro ate, its subsequent pharmacologi­ cal and toxicological characterization, and its clinical development into one of the most widely and successfully used anti epileptic drugs, a real mile­ stone in drug therapy. The current state of knowledge of valproate will be reviewed by experts in the field, including new hypotheses about its mecha­ nisms of action, its metabolism into pharmacologically active metabolites, its unique distribution characteristics, its unwanted hepatotoxic and terato­ genic adverse effects and its various clinical uses. Furthermore, the wide variety of available pharmaceutical formulations of valproate, including novel controlled-release formulations, will be outlined. The monograph is aimed at a broad readership, particularly neurologists, psychiatrists and basic scientists working in the field of epilepsy research. Because the monograph also deals with structure-activity relationships of valproate as well as of its metabolites and analogs, the book should also serve for rese­ archers working in medicinal chemistry, particularly in the pharmaceutical industry.
Citește tot Restrânge

Toate formatele și edițiile

Toate formatele și edițiile Preț Express
Paperback (1) 36436 lei  43-57 zile
  Birkhäuser Basel – 13 oct 2012 36436 lei  43-57 zile
Hardback (1) 64407 lei  43-57 zile
  Birkhauser – 30 iun 1999 64407 lei  43-57 zile

Din seria Milestones in Drug Therapy

Preț: 36436 lei

Preț vechi: 38353 lei
-5% Nou

Puncte Express: 547

Preț estimativ în valută:
6973 7243$ 5792£

Carte tipărită la comandă

Livrare economică 03-17 februarie 25

Preluare comenzi: 021 569.72.76

Specificații

ISBN-13: 9783034897617
ISBN-10: 3034897618
Pagini: 308
Ilustrații: XV, 286 p.
Greutate: 0.49 kg
Ediția:Softcover reprint of the original 1st ed. 1999
Editura: Birkhäuser Basel
Colecția Birkhäuser
Seria Milestones in Drug Therapy

Locul publicării:Basel, Switzerland

Public țintă

Research

Cuprins

The discovery of valproate.- The pharmacology of valproate.- Pharmacological effects and mechanisms of action.- Chemistry and biotransformation.- Absorption, distribution and excretion.- Toxicity.- Clinical use of valproate.- Valproate in the treatment of epilepsies in children.- Treatment of epilepsies in adults.- Valproate use in psychiatry: A focus on bipolar illness.- Valproate in the treatment of headache.- Adverse effects and interactions with other drugs.- The future of valproate.