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Methotrexate: Milestones in Drug Therapy

Editat de Bruce N. Cronstein, Joseph R. Bertino
en Limba Engleză Paperback – 29 oct 2012
Although surprising, it seems fitting that a drug developed at the dawn of the era of rational drug design and therapeutics, methotrexate, should remain in common use for the therapy of so many different kinds of illnesses. Moreover, methotrexate has completely revolutionized the way in which medicine is practiced in a number of speciality areas. First developed to treat malignancies, methotrexate is now commonly used to treat gynecological problems, inflammatory arthritis, skin disease and probably other ailments as well. This work is designed to give a broad overview of the history of methotrexate's development, its prior use and its current therapeutic uses. As discussed in Chapter I, aminopterin and methotrexate were designed to inhibit mammalian folate metabolism but the concept of folic acid antag­ onism was soon applied to the development of antibacterial and anti­ parasitic agents. Trimethoprim and sulfa drugs were among the first antibiotics developed and they also remain quite useful today for the treat­ ment of a variety of infections.
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Specificații

ISBN-13: 9783034895736
ISBN-10: 3034895739
Pagini: 152
Ilustrații: IX, 139 p.
Dimensiuni: 155 x 235 x 8 mm
Greutate: 0.23 kg
Ediția:Softcover reprint of the original 1st ed. 2000
Editura: Birkhäuser Basel
Colecția Birkhäuser
Seria Milestones in Drug Therapy

Locul publicării:Basel, Switzerland

Public țintă

Professional/practitioner

Cuprins

Methotrexate: historical aspects.- Methotrexate, its mechanisms of action in malignant disease and mechanisms of resistance by malignant cells.- Current use of methotrexate in the treatment of malignancies in adults.- The use of methotrexate in the treatment of childhood malignancies.- The mechanisms of methotrexate’s action in the treatment of inflammatory disease.- Methotrexate in rheumatoid arthritis.- Use of methotrexate in the treatment of psoriasis and other dermatological disorders.- The use of methotrexate in gynecological practice.

Descriere

Descriere de la o altă ediție sau format:
This book provides multidisciplinary reviews of the mechanism of action and uses of methotrexate in the treatment of cancer, psoriasis, gynecologic and inflammatory diseases. The intended audience is composed of clinicians involved in the care of patients suffering from oncologic, gynecologic, rheumatic diseases as well as scientists involved in research into the pathogenesis and treatment of these diseases. This boo