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Viruses, Genes, and Cancer de Eric Hunter

Viruses, Genes, and Cancer: Current Topics in Microbiology and Immunology, cartea 407

Editat de Eric Hunter, Klaus Bister
en Limba Engleză Paperback – 11 aug 2018
This volume focuses on virus-host cell interactions, cellular genes acquired or modulated by viruses, the pathological effects of these interactions, and therapeutic interventions. Several chapters specifically address the role of viruses and genes – such as oncogenes, proto-oncogenes, or tumor suppressor genes – in the etiology of human cancer. Oncogenic signaling by PI3 kinase, mTOR, Akt, or the major cancer drivers MYC and RAF, and the role of tumor suppressors like p53, are discussed in detail. The volume also explores the emerging role of noncoding RNAs such as microRNAs in tumorigenesis and cancer therapeutics, and offers new insights into the role of HIV-host interactions relevant to pathogenesis and treatment. Gathering contributions written by leading scientists in their respective fields, the volume offers a valuable resource for researchers and clinicians alike.
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Specificații

ISBN-13: 9783319871677
ISBN-10: 3319871676
Pagini: 221
Ilustrații: XIII, 221 p.
Dimensiuni: 155 x 235 mm
Ediția:Softcover reprint of the original 1st ed. 2017
Editura: Springer International Publishing
Colecția Springer
Seria Current Topics in Microbiology and Immunology

Locul publicării:Cham, Switzerland

Cuprins

Exchange of Genetic Sequences Between Viruses and Host.- Virus-Host Gene Interactions that Define HIV Disease Progression.- Sequencing the Biology of Entry: The Retroviral env Gene.- Infectious Agents in Bovine Red Meat and Milk and Their Potential Role in Cancer and Other Chronic Diseases.- MYC and RAF: Key Effectors in Cellular Signaling and Major Drivers in Human Cancer.- Oncogenic Roles of the PI3K/AKT/mTOR Axis.- MicroRNAs and Cancer.- The Evolution of Tumor Formation in Humans and Mice with Inherited Mutations in the P53 Gene.

Notă biografică

Eric Hunter, PhD, is a Professor of Pathology and Laboratory Medicine and a Georgia Research Alliance Eminent Scholar, based in Atlanta, GA, USA

Klaus Bister, PhD, is a Professor Emeritus of Biochemistry of University of Innsbruck, Austria, and a Professor Adjunct of The Scripps Research Institute, La Jolla, CA, USA  

Textul de pe ultima copertă

This volume focuses on virus-host cell interactions, cellular genes acquired or modulated by viruses, the pathological effects of these interactions, and therapeutic interventions. Several chapters specifically address the role of viruses and genes – such as oncogenes, proto-oncogenes, or tumor suppressor genes – in the etiology of human cancer. Oncogenic signaling by PI3 kinase, mTOR, Akt, or the major cancer drivers MYC and RAF, and the role of tumor suppressors like p53, are discussed in detail. The volume also explores the emerging role of noncoding RNAs such as microRNAs in tumorigenesis and cancer therapeutics, and offers new insights into the role of HIV-host interactions relevant to pathogenesis and treatment. Gathering contributions written by leading scientists in their respective fields, the volume offers a valuable resource for researchers and clinicians alike.

Caracteristici

Includes a foreword by the Nobel laureates J. Michael Bishop and Harold Varmus Casts new light on the role of viruses and genes in the etiology of human cancer Discusses the latest developments in HIV vaccine development Includes supplementary material: sn.pub/extras