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Aminoacyl-tRNA Synthetases in Biology and Medicine de Sunghoon Kim

Aminoacyl-tRNA Synthetases in Biology and Medicine: Topics in Current Chemistry, cartea 344

Editat de Sunghoon Kim
en Limba Engleză Hardback – 13 mai 2014
This book will focus on new molecular interactions and novel activities and the associated diseases that have been recently discovered from the studies of eukaryotic and mammalian aminoacyl-tRNA synthetases. In addition, the potential applications of ARS researches in biotechnology and medicine will be addressed.
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Specificații

ISBN-13: 9789401787000
ISBN-10: 940178700X
Pagini: 360
Ilustrații: X, 350 p.
Dimensiuni: 155 x 235 x 25 mm
Greutate: 0.66 kg
Ediția:2014
Editura: SPRINGER NETHERLANDS
Colecția Springer
Seria Topics in Current Chemistry

Locul publicării:Dordrecht, Netherlands

Public țintă

Research

Cuprins

Catalysis.- Emergence and Evolution.- Architecture.- Protein-protein Interactions and Multicomponent Complexes.- Interactions with RNAs.- Secretion and Circulation.- Regulatory Roles.- Neural Diseases.- Cancer.- Immune Diseases.- Pathologic Implications of Mitochondrial tRNA Synthetases .- Infectious Diseases.- Reprogramming of Genetic Code.- Novel functions of tRNAs.- Perspectives for Systems and Synthetic Bio-Medicine.

Notă biografică

1983–1986 Researcher, Genetic Eng. Center, KAIST, Korea
1991–1994 Post-doc, MIT, USA
1993–1994 Senior Scientist, Cubist Pharmaceuticals, USA
1994-2001 Associate Professor, Sung Kyun Kwan University, Korea
2001-present Professor, College of Pharmacy, Graduate Program in Bioinformatics , Genetic Engineering, Cancer Biology, Seoul National Univ.
1998-present Director, Center for Medicinal Protein Network and Systems Biology, Seoul National University
2008- Director, Information Center of Bio-pharmacological Network
2008- Director, Integrated Bioscience and Biotechnology Institute

Textul de pe ultima copertă

1 Synthetic and Editing Mechanisms of Aminoacyl-tRNA Synthetases
John J. Perona, Ita Gruic-Sovulj
2 Emergence and Evolution
Tammy J. Bullwinkle, Michael Ibba
3 Architecture and Metamorphosis
Min Guo, Xiang-Lei Yang
4 Protein–Protein Interactions and Multi-component Complexes of Aminoacyl-tRNA Synthetases
Jong Hyun Kim, Jung Min Han, Sunghoon Kim
5 Extracellular Activities of Aminoacyl-tRNA Synthetases: New Mediators for Cell–Cell Communication
Sung Hwa Son, Min Chul Park, and Sunghoon Kim
6. Non-catalytic Regulation of Gene Expression by Aminoacyl-tRNA Synthetases
Peng Yao, Kiran Poruri, Susan A. Martinis, Paul L. Fox
7 Amino-Acyl tRNA Synthetases Generate Dinucleotide Polyphosphates as Second Messengers: Functional Implications
Sagi Tshori, Ehud Razin, Hovav Nechushtan
8 Association of Aminoacyl-tRNA Synthetases with Cancer
Doyeun Kim, Nam Hoon Kwon, Sunghoon Kim
9 Pathogenic Implications of Human Mitochondrial Aminoacyl-tRNA Synthetases
Hagen Schwenzer, Joffrey Zoll, Catherine Florentz, Marie Sissler
10 Role of Aminoacyl-tRNA Synthetases in Infectious Diseases and Targets for Therapeutic Development
Varun Dewan, John Reader, Karin-Musier Forsyth
11 Flexizymes, Their Evolutionary History and Diverse Utilities
Toby Passioura, Hiroaki Suga

Caracteristici

Will attract broad readership from basic life science to biotechnology and medical community Describes how aminoacyl-tRNA synthetases give insight into the emergence and evolution of life Shows how the function of a gene can be diversified at protein level Describes how a central metabolism such as protein synthesis is coordinated with other cellular processes Covers ARS-related pathologies and novel activities, which provide new understanding of human diseases and therapeutic opportunities Written by leading experts in the field