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Arrestins - Pharmacology and Therapeutic Potential de Vsevolod V. Gurevich

Arrestins - Pharmacology and Therapeutic Potential: Handbook of Experimental Pharmacology, cartea 219

Editat de Vsevolod V. Gurevich
en Limba Engleză Hardback – 16 dec 2013
This volume describes our current understanding of the biological role of visual and non-visual arrestins in different cells and tissues, focusing on the mechanisms of arrestin-mediated regulation of GPCRs and non-receptor signaling proteins in health and disease. The book covers wide range of arrestin functions, emphasizing therapeutic potential of targeting arrestin interactions with individual partners.
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Specificații

ISBN-13: 9783642411984
ISBN-10: 3642411983
Pagini: 456
Ilustrații: VIII, 447 p. 53 illus., 42 illus. in color.
Dimensiuni: 155 x 235 x 30 mm
Greutate: 1 kg
Ediția:2014
Editura: Springer Berlin, Heidelberg
Colecția Springer
Seria Handbook of Experimental Pharmacology

Locul publicării:Berlin, Heidelberg, Germany

Public țintă

Research

Cuprins

Therapeutic Potential of Small Molecules and Engineered Proteins.-Arrestin Interactions with G Protein-coupled Receptors.- Arrestin-biased GPCR Agonists.- Arrestin-1 Expression Levels, Rod Function and Health.- Protective Functions of Arrestin-1 in Photoreceptors.- Arrestin-4 and Cone Function.- Enhanced Phosphorylation-independent Arrestins and Gene Therapy.- Targeting Particular Receptors with Redesigned Non-visual Arrestins.- Arrestins binding to clathrin, AP2 and Role in GPCR trafficking.- Arrestins in Ubiquitination and Deubiquitination.- Arrestin Self-association.- Arrestin-dependent Activation of ERK and Src.- Arrestin-dependent Activation of JNK Family Kinases.- Arrestin-Mediated P38 Activation.- Arrestin-dependent PDE Localization.- Arrestins in Cell Migration.- Arrestins in Host-pathogen Interactions.- Arrestin Regulation of Small GTPases.- GPCRs and Arrestins in Airways: Implications for Asthma.- Arrestins as Regulatory Signaling Hubs in Cancer Pathways.- Arrestins in Pain and Anesthesia.

Caracteristici

Discusses therapeutic potential of biased ligands of G protein-coupled receptors Describes the molecular mechanisms and therapeutic implications of arrestin-mediated signaling Discusses the potential of reengineered signaling proteins for gene therapy Includes supplementary material: sn.pub/extras