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Bile Acids and Their Receptors: Handbook of Experimental Pharmacology, cartea 256

Editat de Stefano Fiorucci, Eleonora Distrutti
en Limba Engleză Paperback – 19 sep 2020
This book focusses on the latest results related to the field of  bile acids as signaling molecules  and describes how these receptors have become a major pharmacological target. It covers all major areas of research in this field, from genetics, chemistry, in silico modeling, molecular biology to clinical applications, offering a cross-country view of the functional role of bile acids as signaling molecules, virtually acting on all major areas of metabolism. While FXR  and GPBAR1 are essential bile acid sensors that  integrate the de novo bile acid synthesis with intestinal microbiota and  liver metabolism, in a broader sense,  BARs  play a pathogenic role in the development of common human alignments  including  liver, intestinal and metabolic disorders, such as steatosis (NAFLD) and steato-hepatitis (NASH), diabetes, obesity and atherosclerosis. 
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Specificații

ISBN-13: 9783030220075
ISBN-10: 3030220079
Pagini: 378
Ilustrații: X, 378 p. 57 illus., 37 illus. in color.
Dimensiuni: 155 x 235 mm
Greutate: 0.54 kg
Ediția:1st ed. 2019
Editura: Springer International Publishing
Colecția Springer
Seria Handbook of Experimental Pharmacology

Locul publicării:Cham, Switzerland

Cuprins

Preface.- Part 1. Bile acids   as   signaling molecules  and their  receptors.- 1. A short history of bile acid pharmacology.- 2. Bile acids  activated receptors: a review of  GPBAR1  (TGR5) and other G-protein-coupled receptors.- 3. Bile acid activated receptors: a review of FXR and other Nuclear receptors.- 4. The intestinal enterokine fibroblast growth factor 15/19 in bile acid metabolism.- 5. Signaling from intestine to  the host. How bile acids regulate intestinal and liver immunity.- Part 2.  General pharmacology of  bile acid activated receptors and their ligands.- 6. Modeling of bile acid activated receptors as a tool for pharmacological development.- 7. Chemistry and pharmacology of GPBAR1 and  FXR selective agonists, dual agonists and antagonists.- 8. Non steroidal FXR ligands: current status and  clinical applications.- 9.  Intestinal selective FXR agonists and their potential in treating liver and metabolic diseases.- Part 3. Bile acids and their derivatives as drugs.- 10. UDCA, Nor-UDCA and T-UDCA: a review of their mechanisms of action and clinical applications.- 11. Chenodeoxycholic acid: an update on its therapeutic appplications and safety profile.- 12. Obeticholic acid: a review of   its mechanisms of action and  clinical applications.- Part 4. Bile acid activated receptors as therapeutic targets.- 13. Targeting FXR in cholestasis.- 14. FXR agonists for the treatment of NASH and other  metabolic disorders.- 15. Targeting bile acids activated receptors in bariatric surgery.

Caracteristici

Gives an overview on latest findings in the novel field of research of bile acids as signaling molecules Offers a cross-country view of the functional role of bile acids as signaling molecules, virtuallyacting on all major areas of metabolism Describes different approaches of bile acids pharmacology by providing authors' diverse perspectives