Cantitate/Preț
Produs

Centromere: Structure and Evolution: Progress in Molecular and Subcellular Biology, cartea 48

Editat de Durdica Ugarkovic
en Limba Engleză Hardback – 29 mai 2009
The centromere is a chromosomal region that enables the accurate segregation of chromosomes during mitosis and meiosis. It holds sister chromatids together, and through its centromere DNA–protein complex known as the kinetochore binds spindle microtubules to bring about accurate chromosome movements. Despite this conserved function, centromeres exhibit dramatic difference in structure, size, and complexity. Extensive studies on centromeric DNA revealed its rapid evolution resulting often in significant difference even among closely related species. Such a plasticity of centromeric DNA could be explained by epigenetic c- trol of centromere function, which does not depend absolutely on primary DNA sequence. According to epigenetic centromere concept, which is thoroughly d- cussed by Tanya Panchenko and Ben Black in Chap. 1 of this book, centromere activation or inactivation might be caused by modifications of chromatin. Such acquired chromatin epigenetic modifications are then inherited from one cell di- sion to the next. Concerning centromere-specific chromatin modification, it is now evident that all centromeres contain a centromere specific histone H3 variant, CenH3, which replaces histone H3 in centromeric nucleosomes and provides a structural basis that epigenetically defines centromere and differentiates it from the surrounding chromatin. Recent insights into the CenH3 presented in this chapter add important mechanistic understanding of how centromere identity is initially established and subsequently maintained in every cell cycle.
Citește tot Restrânge

Toate formatele și edițiile

Toate formatele și edițiile Preț Express
Paperback (1) 92073 lei  6-8 săpt.
  Springer Berlin, Heidelberg – 19 oct 2010 92073 lei  6-8 săpt.
Hardback (1) 92816 lei  6-8 săpt.
  Springer Berlin, Heidelberg – 29 mai 2009 92816 lei  6-8 săpt.

Din seria Progress in Molecular and Subcellular Biology

Preț: 92816 lei

Preț vechi: 113190 lei
-18% Nou

Puncte Express: 1392

Preț estimativ în valută:
17763 18451$ 14755£

Carte tipărită la comandă

Livrare economică 04-18 februarie 25

Preluare comenzi: 021 569.72.76

Specificații

ISBN-13: 9783642001819
ISBN-10: 3642001815
Pagini: 170
Ilustrații: X, 184 p. 35 illus., 15 illus. in color.
Dimensiuni: 155 x 235 x 17 mm
Greutate: 0.5 kg
Ediția:2009
Editura: Springer Berlin, Heidelberg
Colecția Springer
Seria Progress in Molecular and Subcellular Biology

Locul publicării:Berlin, Heidelberg, Germany

Public țintă

Research

Cuprins

The Epigenetic Basis for Centromere Identity.- The Centromere-Drive Hypothesis: A Simple Basis for Centromere Complexity.- Centromere-Competent DNA: Structure and Evolution.- The Role of ncRNA in Centromeres: A Lesson from Marsupials.- Evolutionary New Centromeres in Primates.- Structure and Evolution of Plant Centromeres.

Textul de pe ultima copertă

The centromere is a chromosomal locus that regulates the proper pairing and segregation of the chromosomes during cell division. Despite their conserved, essential function, centromeres are characterized by the rapid evolution of both centromeric DNA and proteins.
This book presents current views on centromere structure and identity. It deals with the epigenetic concept of centromere establishment and maintenance as well as with the role of DNA and centromeric transcripts in centromere formation and function. Special emphasis is placed on centromere evolution: different evolutionary models are discussed in detail and the latest research on the evolution of new centromeres and neocentromeres is presented.

Caracteristici

Unique overview on the centromere research of the last decade Special focus on centromere evolution