Chemical Mutagens de Alexander Hollaender

Chemical Mutagens: Principles and Methods for Their Detection Volume 4

Alexander Hollaender

en Limba Engleză Paperback – 19 mar 2012

As editor I want especially to thank Dr. Ernst Freese for helpful co operation in preparing these volumes, and to express my appreclatlOn to Drs. Kurt Hirschhorn and Marvin Legator, the other members of the editorial board. Alexander Hollaender January 1971 Preface The purpose of these volumes is to encourage the development and ap plication of testing and monitoring procedures to avert significant human exposure to mutagenic agents. The need for protection against exposure to possibly mutagenic chemicals is only now coming to be generally realized. The recently issued Report of the Secretary's Commission on Pesticides and Their Possible Effects on Health (the Mrak Report-U.S. Department of Health, Education and Welfare, December 1969) has made an important start. Its Panel on Mutagenicity recommends that all currently used pesticides be tested for mutagenicity in several recently developed and relatively simple systems. Whether recommendations such as these are actually put into effect will depend on convincing government, industry, and the public that the problem is important, that the proposed tests would be effective, and that they can be conducted at a cost that is not prohibitive. Why is it important to screen environmental agents for mutagenic activity? To those who will read this book, the answer is self-evident. The sine qua non of all that we value and all that we are is our genetic heritage.

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Express

Paperback (4)

355^.97 lei 6-8 săpt.

Springer Us – 5 feb 2012

355^.97 lei 6-8 săpt.

Springer Us – 18 feb 2012

358^.41 lei 6-8 săpt.

Springer Us – 19 mar 2012

358^.60 lei 6-8 săpt.

Springer Us – 10 sep 2012

691^.48 lei 6-8 săpt.

Cuprins

of Volume 3.- 24 History of Research on Chemical Mutagenesis.- I. Introduction.- II. War Gases.- III. Other Alkylating Agents.- IV. Nitroso Compounds.- V. Urethane.- VI. Alkaloids.- VII. Inorganic Salts.- VIII. Formaldehyde, Organic Peroxides.- IX. Nitrous Acid.- X. Calf Thymus DNA and Other Macromolecules, Carcinogens.- XI Phenols.- XII. Basic Dyes.- XIII. Purines.- XIV. Base Analogues.- XV. Epilogue.- XVI. References.- 25 Observations on Meiotic Chromosomes of the Male Mouse as a Test of the Potential Mutagenicity of Chemicals in Mammals.- I. Introduction.- II. Methods for Detecting Chromosome Aberrations.- III. Experimental Results with Ionizing Radiation.- IV. Experimental Results with Chemical Mutagens.- V. Acknowledgments.- VI. References.- 26 Techniques for Monitoring and Assessing the Significance of Mutagenesis in Human Populations.- I. Introduction.- II. Kinds of Information about Human Populations Needed for Monitoring.- III. Limitations and Advantages of Using Existing Population Records.- IV. Information Content of the Available Records.- V. Methods of Record Linkage.- VI. Relevant Data Obtained by Record Linkage.- VII. Future Accessibility of Diagnostic Data.- VIII. Mutagenesis and the Search for an Optimum Environment for Man.- IX. Conclusions for Geneticists.- X. References.- 27 Specific-Locus Mutational Assay Systems for Mouse Lymphoma Cells.- I. Introduction.- II. HGPRT Locus.- III. TK Locus: General Principles.- IV. TK Locus in a Mutational Assay System.- V. Concluding Remarks.- VI. Acknowledgments.- VII. References.- 28 Approaches to Monitoring Human Populations for Mutation Rates and Genetic Disease.- I. Introduction.- II. Theoretical Importance of Measurements in Man.- III. Practical Importance of Human Genetic Monitoring.- IV. Study of Mutation atthe Molecular Level.- V. Critique of Genetic Monitoring Based on Electrophoresis.- VI. Does the Initial Approach Meet the Criteria for a Satisfactory Monitoring System?.- VII. Estimates of the Magnitude of Effort Required.- VIII. Importance of Accurate Information.- IX. Some Technological Requirements.- X. Assessment of Technological Possibilities (Using Electrophoresis).- XI. Methods Based on Activity Measurements.- XII. Low Molecular Weight Substances.- XIII. Confirmatory Analyses, Genetic Follow-up, and Data Reduction.- XIV. Genetic Monitoring as a National Problem.- XV. Conclusions.- XVI. References.- 29 Repair of Chemical Damage to Human DNA.- I. Introduction.- II. Sequence of Molecular Events in Experiments with Mutagenic and Carcinogenic Agents.- III. What Can DNA Repair Studies Tell Us?.- IV. Methods of Studying Repair.- V. The Two Forms of Repair as Measured by BrUra Photolysis.- VI. Classification of DNA-Damaging Chemical Agents According to the Repair Sequence Induced.- VII. Xeroderma Pigmentosum and UV-Type Repair after Chemical Damage to DNA.- VIII. Summary of Present Interpretations.- IX. Acknowledgments.- X. References.- 30 Tradescantia Stamen Hairs: A Radiobiological Test System Applicable to Chemical Mutagenesis.- I. Introduction.- II. Techniques and Procedures.- III. Characteristic Data Obtained from the Stamen-Hair System.- IV. Summary.- V. Acknowledgments.- VI. References.- 31 Detection of Genetically Active Chemicals Using Various Yeast Systems.- I. Brief Description of the Yeasts Used in Genetic Research.- II. Techniques.- III. Treatment Conditions.- IV. Systems Used to Detect Mutagenicity of Chemicals.- V. Evaluation of Mutagenesis Experiments and Complications.- VI. The Problem of Metabolic Activation.- VII. Mitotic Recombination.- VIII. MethodsUsed to Increase Sensitivity to Genetically Active Agents.- IX. General Evaluation.- X. Acknowledgments.- XI. References.- 32 Total Reproductive Capacity in Female Mice: Chemical Effects and Their Analysis.- I. Introduction.- II. Oocyte Development and Responses to Radiation Effects.- III. General Procedure.- IV. Fertility Effects of Alkylating Chemicals on Female Mice.- V. Delayed Pathological and Survival Effects in Chemically Treated Female Mice in the Total Reproductive Capacity Experiment.- VI. Importance of Using Females in Fertility Studies.- VII. Need for Assay Systems in Female Mice to Measure Induced Heritable Genetic Damage.- VIII. References.- 33 Insect Chemosterilants as Mutagens.- I. Introduction.- II. Screening of Chemosterilants.- III. Classification of Chemosterilants.- IV. Conclusion.- V. References.- 34 The Literature of Chemical Mutagenesis.- I. Introduction.- II. The State of Chemical Mutagenesis Literature.- III. Sources and Types of Chemical Mutagenesis Literature.- IV. Organization of Chemical Mutagenesis Information.- V. Some Suggestions for Improving Literature Control.- VI. Conclusion.- VII: Acknowledgments.- Author Index.