Conditional Mutagenesis: An Approach to Disease Models: Handbook of Experimental Pharmacology, cartea 178
Editat de Robert Feil, Daniel Metzgeren Limba Engleză Hardback – 28 noi 2006
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Specificații
ISBN-13: 9783540351085
ISBN-10: 3540351086
Pagini: 544
Ilustrații: XII, 532 p.
Dimensiuni: 155 x 235 x 35 mm
Greutate: 0.93 kg
Ediția:2007
Editura: Springer Berlin, Heidelberg
Colecția Springer
Seria Handbook of Experimental Pharmacology
Locul publicării:Berlin, Heidelberg, Germany
ISBN-10: 3540351086
Pagini: 544
Ilustrații: XII, 532 p.
Dimensiuni: 155 x 235 x 35 mm
Greutate: 0.93 kg
Ediția:2007
Editura: Springer Berlin, Heidelberg
Colecția Springer
Seria Handbook of Experimental Pharmacology
Locul publicării:Berlin, Heidelberg, Germany
Public țintă
ResearchCuprins
Tools for Conditional Mutagenesis.- Conditional Somatic Mutagenesis in the Mouse Using Site-Specific Recombinases.- Cre/loxP-Mediated Chromosome Engineering of the Mouse Genome.- Tetracycline-Controlled Genetic Switches.- Novel Gene Switches.- Improved Embryonic Stem Cell Technologies.- Gene Trap Mutagenesis.- RNA Interference in Mice.- Viral Vectors: A Wide Range of Choices and High Levels of Service.- Conditional Mutagenesis by Cell-Permeable Proteins: Potential, Limitations and Prospects.- Examples of Conditional Disease Models.- Analysis of Mouse Development with Conditional Mutagenesis.- Conditional Mouse Models of Cancer.- Conditional Mutagenesis Reveals Immunological Functions of Widely Expressed Genes: Activation Thresholds, Homeostatic Mechanisms and Disease Models.- Conditional Transgenesis and Recombination to Study the Molecular Mechanisms of Brain Plasticity and Memory.- A Novel Conditional Knockout Strategy Applied to Serotonin Receptors.- Conditional Mouse Models for Friedreich Ataxia, a Neurodegenerative Disorder Associating Cardiomyopathy.- Animal Models in Cardiovascular Diseases: New Insights from Conditional Models.- Conditional Animal Models for the Study of Lipid Metabolism and Lipid Disorders.- Conditional Mouse Models to Study Developmental and Pathophysiological Gene Function in Muscle.- Analysis of Calcium Channels by Conditional Mutagenesis.- Conditional Mutagenesis of G-Protein Coupled Receptors and G-Proteins.- Contribution of Targeted Conditional Somatic Mutagenesis to Deciphering Retinoid X Receptor Functions and to Generating Mouse Models of Human Diseases.
Recenzii
From the reviews:
"This is a comprehensive overview of generating mouse models with conditional modification of genes to study the effects of gene dysfunction in the development of human diseases. … The authors target general scientific researchers … . This book will be very informative for any scientists and students interested in using or generating genetically modified mouse models in biomedical research. … an excellent reference on the most recent progress in generating conditional knockout mice." (Grace L Guo, Doody’s Review Service, July, 2008)
"This is a comprehensive overview of generating mouse models with conditional modification of genes to study the effects of gene dysfunction in the development of human diseases. … The authors target general scientific researchers … . This book will be very informative for any scientists and students interested in using or generating genetically modified mouse models in biomedical research. … an excellent reference on the most recent progress in generating conditional knockout mice." (Grace L Guo, Doody’s Review Service, July, 2008)
Caracteristici
Includes supplementary material: sn.pub/extras