In this issue of Veterinary Clinics: Exotic Animal Practice, guest editor Dr. Lily Parkinson brings her considerable expertise to the topic of Critical Care. With today's improved emergency care, further advanced, nuanced, and prolonged critical care is required. Focusing on the critical care of exotic animal patients after the initial emergency triage and stabilization, this issue discusses aspects of critical care as they relate to many different species, which all have unique physiologies and requirements for their optimal care.