In this issue of Veterinary Clinics: Small Animal Practice, guest editors Drs. Thomas K. Graves and Chen Gilor bring their considerable expertise to the topic of Diabetes Mellitus in Cats and Dogs. Top experts in the field cover key topics such as hypoglycemia and autonomic failure in dogs; anesthetic considerations in dogs and cats with diabetes mellitus; insulin therapy in dogs and cats; hypersomatotropism and other causes of insulin resistance in cats; and more.