In this issue of Veterinary Clinics: Exotic Animal Practice, guest editor Dr. David Sanchez-Migallon Guzman brings his considerable expertise to the topic of Pain Management. Pain management is an important component of exotic veterinary care, and major advances have been made in this area in recent years. With this issue, readers will lean how to recognize, assess, and treat pain in zoological companion species through clinically oriented and evidence-based articles by top experts in the field.