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Curing Genetic Diseases through Genome Reprogramming: Progress in Molecular Biology and Translational Science, cartea 182

Gianluca Petris
en Limba Engleză Hardback – 23 iun 2021
Curing Genetic Diseases through Genome Reprogramming, Volume 182 captures an historic moment in the field of gene therapy—the dawn of a new age in which the dream of curing genetic diseases has become realizable. The volume presents the most clinically advanced gene therapy and genome editing approaches for the treatment of genetic diseases in specific organs, including difficult therapeutic targets, futuristic ideas of genetic interventions, and large scale human genome repair. An initial chapter addresses the complex ethical aspects involved in the very idea of modifying the human genome.

  • Provides a comprehensive view of gene therapy and genome editing technologies, including epigenetic editing
  • Describes the state-of-the-art and future directions for the treatment of genetic diseases, also considering economical aspects
  • Presents chapters that each give a thorough review of a specific disease, target organ or visionary approach, including ethical considerations
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Specificații

ISBN-13: 9780323853019
ISBN-10: 0323853013
Pagini: 558
Dimensiuni: 152 x 229 mm
Greutate: 0.91 kg
Editura: ELSEVIER SCIENCE
Seria Progress in Molecular Biology and Translational Science


Public țintă

A comprehensive source of information for biologists, biotechnologists and students interested in gene therapy and genome editing, but also for medical doctors, stakeholders and policy makers who are intrigued by innovative genetic therapies.

Cuprins

Preface
Gianluca Petris
1. Making sense of heritable human genome editing: scientific and ethical considerations
Andy Greenfiel
2. CRISPR genome engineering for retinal diseases
Ariel Kantor, Michelle E. McClements, Caroline F. Peddle, Lewis E. Fry, Ahmed Salman, Jasmina Cehajic-Kapetanovic, Kanmin Xue and Robert E. MacLaren
3. Advances in gene editing strategies for epidermolysis bullosa
Thomas Kocher and Ulrich Koller
4. Targeted genome editing for the correction or alleviation of primary immunodeficiencies
Christopher J. Sipe, Patricia N. Claudio Vázquez, Joseph G. Skeate, R. Scott McIvor and Branden S. Moriarity
5. Genome editing approaches to β-hemoglobinopathies
Mégane Brusson and Annarita Miccio
6. Rewriting CFTR to cure Cystic Fibrosis
Giulia Maule, Marjolein Ensinck, Mattijs Bulcaen and Marianne S. Carlon
7. Gene editing and modulation for Duchenne muscular dystrophy
Anthony A. Stephenson and Kevin M. Flanigan
8. Genome editing in the human liver: progress and translational considerations
Samantha L. Ginn, Sharntie Christina and Ian E. Alexander
9. Genome editing in lysosomal disorders
Luisa Natalia Pimentel-Vera, Edina Poletto, Esteban Alberto Gonzalez, Fabiano de Oliveira Poswar, Roberto Giugliani and Guilherme Baldo
10. Genome editing in mucopolysaccharidoses and mucolipidoses
Hallana Souza Santos, Edina Poletto, Roselena Schuh, Ursula Matte and Guilherme Baldo
11. Gene and epigenetic editing in the treatment of primary ciliopathies
Elisa Molinari and John A. Sayer
12. Genome editing in stem cells for genetic neurodisorders
Dell'Amico Claudia, Tata Alice, Pellegrino Enrica, Onorati Marco and Conti Luciano
13. Reprogramming translation for gene therapy
Chiara Ambrosini, Francesca Garilli and Alessandro Quattrone
14. Synthetic genomics for curing genetic diseases
Simona Grazioli and Gianluca Petris