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DNA and Histone Methylation as Cancer Targets de Atsushi Kaneda

DNA and Histone Methylation as Cancer Targets: Cancer Drug Discovery and Development

Editat de Atsushi Kaneda, Yu-ichi Tsukada
en Limba Engleză Hardback – 12 sep 2017
This book will focus on DNA and histone methylation in epigenetics and describe how it is involved in the molecular mechanisms responsible for the development of cancer. Chapters will summarize the current knowledge of the molecular basis of DNA and histone methylation and explain how it is involved in cancer, describe the features of DNA and histone methylation associated with particular types of cancer, diagnostic/therapeutic applications, and future directions of DNA and histone methylation as cancer targets.
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Specificații

ISBN-13: 9783319597843
ISBN-10: 3319597841
Pagini: 1170
Ilustrații: VIII, 624 p. 91 illus., 81 illus. in color.
Dimensiuni: 155 x 235 mm
Greutate: 1.05 kg
Ediția:1st ed. 2017
Editura: Springer International Publishing
Colecția Humana
Seria Cancer Drug Discovery and Development

Locul publicării:Cham, Switzerland

Cuprins

DNA and histone methylation in epigenetics.- The molecular basis of DNA methylation.- The molecular basis of DNA demethylation.- DNA methylation changes in cancer.- Misregulation of DNA methylation regulators in cancer.- The molecular basis of histone methylation.- The molecular basis of histone demethylation.- Misregulation of histone methylation regulators in cancer.- Other histone modifications.- DNA methylation and dysregulation of miRNA in cancer.- Genomic imprinting syndromes and cancer.- DNA and Histone Methylation in Brain Cancer.- DNA and Histone Methylation in Gastric Cancer.- DNA and Histone Methylation in Hematopoietic malignancy.- DNA and Histone methylation in Lung cancer.- DNA and Histone Methylation in Liver Cancer.- DNA and Histone Methylation in Colon Cancer.- DNA and histone methylation in prostate cancer.- DNA and histone modifications in cancer diagnosis.- DNA and histone modifications in cancer therapy.- Future perspective of DNA and histone methylation as cancer targets.

Notă biografică

Atsushi Kaneda, MD, PhD, is Professor, Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan.

Yu-ichi Tsukada, PhD, is Professor, Advanced Biological Information Research Division, INAMORI Frontier Research Center, Kyushu University, Fukuoka, Fukuoka, Japan

Textul de pe ultima copertă

This book will focus on DNA and histone methylation in epigenetics and describe how it is involved in the molecular mechanisms responsible for the development of cancer. Chapters will summarize the current knowledge of the molecular basis of DNA and histone methylation and explain how it is involved in cancer, describe the features of DNA and histone methylation associated with particular types of cancer, diagnostic/therapeutic applications, and future directions of DNA and histone methylation as cancer targets.

Caracteristici

Describes the features of DNA and histone methylation associated with particular types of cancer Compiles the current knowledge of the molecular basis of DNA and histone methylation and contextualizes it within cancer Presents analysis methods, diagnostic/therapeutic applications, and future directions of DNA and histone methylation as cancer targets