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GABAB Receptor de Giancarlo Colombo

GABAB Receptor: The Receptors, cartea 29

Editat de Giancarlo Colombo
en Limba Engleză Hardback – 28 dec 2016
An up-to-date comprehensive overview of the GABA B receptor system with a particular focus on the most recent therapeutic applications and potential. This receptor system has recently been implicated in several diseases and disorders including gastroesophageal reflux disease, epilepsy, mood disorders, depression, and alcohol and substance use disorder. The authors, leading researchers in the field, explore a number of approaches, including medicinal chemistry, molecular biology, physiology, and preclinical and clinical pharmacology. This overview provides a translational perspective on the potential of the GABA B receptor pharmacology.
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Specificații

ISBN-13: 9783319460420
ISBN-10: 3319460420
Pagini: 400
Ilustrații: XX, 385 p. 64 illus., 19 illus. in color.
Dimensiuni: 155 x 235 x 28 mm
Greutate: 0.91 kg
Ediția:1st ed. 2016
Editura: Springer International Publishing
Colecția Humana
Seria The Receptors

Locul publicării:Cham, Switzerland

Cuprins

1. Historical Perspectives on the GABAB Receptor.- Section 1. Chemistry.- 2. Chemistry of GABAB Receptor Ligands: Focus on Agonists and Antagonists.- 3. Chemistry of GABAB Receptor Ligands: Focus on Positive Allosteric Modulators.- Section 2. Molecular Biology, Biochemistry, & Physiology.- 4. Molecular Structure and Trafficking of the GABAB Receptor.- 5. Distribution and Localization of the GABAB Receptor.- 6. Activation Mechanism and Allosteric Properties of the GABAB Receptor.- 7. Modulation of Neurotransmission by the GABAB Receptor.- 8. GABAB Receptor Functions In The Mesolimbic Dopamine System.- Section 3. Pharmacology.- 9. Drug Discrimination Studies for Investigations on the Mechanisms of Action of GABAB Receptor Ligands.- 10. Targeting the GABAB Receptor for the Treatment of Epilepsy.- 11. Targeting the GABAB Receptor for the Treatment of Pain.- 12. Targeting the GABAB Receptor for the Treatment of Psychiatric Disorders.- 13. Targeting the GABAB Receptor for the Treatment of Fragile X Syndrome and Autism Spectrum Disorders.- 14. Targeting the GABAB Receptor for the Treatment of Substance Use Disorder.- 15. Targeting the GABAB Receptor for the Treatment of Alcohol Use Disorder.- 16. Targeting GABAB Receptors for the Treatment of Gastroesophageal Reflux Disease and Chronic Cough.- 17. Baclofen: Therapeutic Use and Potential of the Prototypic GABAB Receptor Agonist.- 18. Allosteric Modulators: The New Generation of GABAB Receptor Ligands.- 19. GABAB Receptor Antagonists as Cognition Enhancers.

Notă biografică

Giancarlo Colombo is a researcher at the Neuroscience Institute, Section of Cagliari, National Research Council of Italy. He has previously worked at the Laboratory of Physiologic and Pharmacologic Studies, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA, and the Department of Physiology and Pharmacology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC, USA.
His research interest is primarily on neurobiology and pharmacology of alcohol use disorder, with focus on the role of GABAB receptor in the control of multiple alcohol-related behaviors and the development of GABAB receptor ligands as possible pharmacotherapies for alcohol use disorder.
He has published approximately 200 papers in peer-reviewed journals and about 20 book chapters. He serves on the editorial board of the journals Alcohol and Alcohol and Alcoholism.

Textul de pe ultima copertă

An up-to-date comprehensive overview of the GABA B receptor system with a particular focus on the most recent therapeutic applications and potential. This receptor system has recently been implicated in several diseases and disorders including gastroesophageal reflux disease, epilepsy, mood disorders, depression, and alcohol and substance use disorder. The authors, leading researchers in the field, explore a number of approaches, including medicinal chemistry, molecular biology, physiology, and preclinical and clinical pharmacology. This overview provides a translational perspective on the potential of the GABA B receptor pharmacology.

Caracteristici

Focuses on recent therapeutic applications and future potential for drug discovery Bench-to-bedside" translational approach Explores different perspectives from various fields of study including medical medicinal chemistry, molecular biology, physiology, and preclinical and clinical pharmacology Explores specific diseases and disorders in which GABAB receptors have been implicated recently