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Good Research Practice in Non-Clinical Pharmacology and Biomedicine: Handbook of Experimental Pharmacology, cartea 257

Editat de Anton Bespalov, Martin C. Michel, Thomas Steckler
en Limba Engleză Hardback – 21 feb 2020
This open access book, published under a CC BY 4.0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical pharmacology and biomedicine.
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Specificații

ISBN-13: 9783030336554
ISBN-10: 3030336557
Pagini: 423
Ilustrații: X, 423 p. 34 illus., 21 illus. in color.
Dimensiuni: 155 x 235 mm
Greutate: 0.79 kg
Ediția:1st ed. 2020
Editura: Springer International Publishing
Colecția Springer
Seria Handbook of Experimental Pharmacology

Locul publicării:Cham, Switzerland

Cuprins

1. Quality in Non-GxP Research Environment.- 2. Guidelines & Initiatives for Good Research Practice.- 3. Learning from principles of evidence-based medicine to optimize nonclinical research practices.- 4. General Principles of Preclinical Study Design.- 5. Resolving the tension between exploration and confirmation in preclinical biomedical research.- 6. Blinding and Randomization.- 7. Out of control?  Managing baseline variability in experimental studies with control groups.- 8. Quality of Research Tools.- 9. Genetic background and sex: impact on generalizability of research findings in pharmacology studies.- 10. Building robustness intro translational research.- 11. Minimum information and quality standards for conducting, reporting, and organizing in vitro research.- 12. Minimum Information in In Vivo Research.- 13. A reckless guide to P-values: Local evidence, global errors.- 14. Electronic Lab Notebooks and Experimental Design Assistants.- 15. Data storage.- 16. Design of meta-analysis studies.- 17. Publishers’ responsibilities in promoting data quality and reproducibility.- 18. Quality governance in biomedical research.- 19. Good Research Practice – Lessons from Animal Care & Use.- 20. Research collaborations and quality in research: foes or friends?.- 21. Costs of implementing quality in research practice.

Textul de pe ultima copertă

This open access book, published under a CC BY 4.0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical pharmacology and biomedicine.

Caracteristici

First comprehensive book on factors associated with high risk for poor reproducibility of non-clinical findings Inclusion of aspects of study design, data analysis and data reporting Broad applicability to in vitro and in vivo research across all therapeutic areas