This briefs offers a comprehensive view of the journey of grandparents of children with disabilities by employing a wide range of theoretical approaches such as intergenerational relationships, positive psychology, psychoanalytic views and models of stress. It presents a multidimensional view of grandparents, which begins with the general role of grandparents in the family and the transition to grandparenthood, as a major life event. The briefs moves on to discuss grandparents’ roles under unique circumstances such as illness or disability in the family and then deals with perspectives of parents of children with disabilities on the role of grandparents. Finally, it reviews attitudes of professionals toward grandparents and concludes with suggested intervention strategies for working with families on intergenerational relationships.