This issue of Orthopaedic Clinics will focus on infection. This issue will include articles on: Charcot Arthropathy versus Osteomyelitis: Evaluation and Management; Physical function, and physical activity in obese adults after total knee arthroplasty; DVT and PE Considerations in Orthopaedic Surgery; The Impact of Negative Pressure Wound Therapy on Orthopaedic Infection; Role of Systemic and Local Antibiotics in the Treatment of Open Fractures; Acute Hematogenous Osteomyelitis in Children; and many more!