Isolation and Molecular Characterization of Circulating Tumor Cells: Advances in Experimental Medicine and Biology, cartea 994
Editat de Mark Jesus M. Magbanua, John W. Parken Limba Engleză Paperback – 2 aug 2018
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Specificații
ISBN-13: 9783319857879
ISBN-10: 3319857878
Ilustrații: XVI, 301 p. 42 illus., 15 illus. in color.
Dimensiuni: 155 x 235 mm
Greutate: 0.45 kg
Ediția:Softcover reprint of the original 1st ed. 2017
Editura: Springer International Publishing
Colecția Springer
Seria Advances in Experimental Medicine and Biology
Locul publicării:Cham, Switzerland
ISBN-10: 3319857878
Ilustrații: XVI, 301 p. 42 illus., 15 illus. in color.
Dimensiuni: 155 x 235 mm
Greutate: 0.45 kg
Ediția:Softcover reprint of the original 1st ed. 2017
Editura: Springer International Publishing
Colecția Springer
Seria Advances in Experimental Medicine and Biology
Locul publicării:Cham, Switzerland
Cuprins
Preface.- Circulating Tumor Cells as Cancer Biomarkers.- Strategies for Isolation and Molecular Profiling of Circulating Tumor Cells.- Aptamer-Based Methods for Detection of Circulating Tumor Cells and Their Potential for Personalized Diagnostics.- Development of a Protocol for Single-Cell Analysis of Circulating Tumor Cells in Patients with Solid Tumors.- Flow Cytometric Methods for Circulating Tumor Cell Isolation and Molecular Analysis.- Enrichment and Detection of Circulating Tumor Cells and Other Rare Cell Populations by Microfluidic Filtration.- Detection and Enumeration of Circulating Tumor Cells with Invasive Phenotype.- Molecular Profiling and Significance of Circulating Tumor Cell Based Genetic Signatures.- Detection of Gene-Rearrangements in Circulating Tumor Cells: Examples of ALK-, ROS1-, RET-Rearrangements in Non-Small-Cell Lung Cancer and ERG-Rearrangements in Prostate Cancer.- Enrichment, Isolation, and Molecular Characterization of EpCAM-Negative Circulating Tumor Cells.- Expression of Epithelial Mesenchymal Transition and Cancer Stem Cell Markers in Circulating Tumor Cells.
Textul de pe ultima copertă
The past decade has seen remarkable progress in elucidating the clinical relevance of circulating tumor cells (CTCs). Evidence from numerous clinical studies has unequivocally demonstrated the importance of CTCs as harbingers of poor outcome. Despite these advances, the molecular nature of CTCs remains elusive. This is in part due to the difficulty in isolating pure CTCs away from blood cells.
Recent advancements in rare-cell technology have provided solutions to the once daunting task of isolating extremely rare CTCs in the blood of cancer patients. This book presents different novel approaches for detection and purification of CTCs. In addition, the readers are introduced to new technologies for molecular profiling of CTCs, including techniques to overcome limitations posed by the paucity of cells and the biomolecules available for downstream molecular analysis.
This book is particularly relevant to scientists and academicians who are interested in the field of CTC research. It provides an overview of the recent technological advances in CTC isolation and profiling. This work also includes discussions on pertinent issues regarding the biology of CTCs, and their potential utility as liquid biopsy for personalized medicine. We hope that this book stimulate further research and help advance our understanding of the molecular biology of CTCs.
Recent advancements in rare-cell technology have provided solutions to the once daunting task of isolating extremely rare CTCs in the blood of cancer patients. This book presents different novel approaches for detection and purification of CTCs. In addition, the readers are introduced to new technologies for molecular profiling of CTCs, including techniques to overcome limitations posed by the paucity of cells and the biomolecules available for downstream molecular analysis.
This book is particularly relevant to scientists and academicians who are interested in the field of CTC research. It provides an overview of the recent technological advances in CTC isolation and profiling. This work also includes discussions on pertinent issues regarding the biology of CTCs, and their potential utility as liquid biopsy for personalized medicine. We hope that this book stimulate further research and help advance our understanding of the molecular biology of CTCs.
Caracteristici
Informative and authoritative, this book presents state-of-the-art strategies for CTC research from experts and key opinion leaders in the field This book contains creative and innovative ideas for rare-cell detection and isolation This book offers comprehensive discussions on the current understanding of the molecular biology of CTCs, as well as highly advanced and in-depth approaches for molecular characterization of these cells TThis book includes discussions on the potential clinical utility of CTCs and how these cells may be incorporated into routine medical practice and personalized medicine