Mineralizing Vesicles: From Biochemical and Biophysical Properties to Their Roles in Physiology and Disease
Editat de Massimo Bottini, Ana Paula Ramosen Limba Engleză Paperback – 21 noi 2023
The first chapter presents foundational biochemical and biological aspects of EVs. Next, the title coves the role of EVs in bone ossification and in cardiovascular and cartilage-related diseases. Considering the unique ability of this class of EVs to form apatite minerals assigned to their special biochemical machinery, three chapters of the book then focus on the enzymes catalysing the inorganic phosphate and calcium turn-over and the dynamic properties of the vesicles’ peripheral proteins. Chapters describe the role of inorganic phosphate and calcium ions and of autophagy on the biogenesis and function of mineralizing EVs. Recent studies show that the lumen of mineralizing EVs is partially filled with miRNA, and a chapter therefore considers research on the possible function of these vesicles as signalosomes. The final five chapters of the book describe practical aspects of working with mineralizing EVs, including their purification, proteomic and biophysical analyses, the use of biomimetic models and mineralizing EVs in regenerative medicine.
This title presents, for the first time, a comprehensive account of mineralizing EVs and their potential clinical applications. It will be invaluable to researchers in the field.
• Covers all aspects of mineralizing EVs, from their composition to their function in physiological and pathological processes, and their clinical potential
• Presents mineralizing EVs systematically using clear accessible language
• Describes practical aspects of working with mineralizing EVs
• Integrates an account of the biochemistry and biophysics of vesicles with their functions
• Takes a multidisciplinary perspective, offering an exhaustive and cutting-edge account of mineralizing EVs and human health
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Specificații
ISBN-13: 9780323991582
ISBN-10: 0323991580
Pagini: 448
Dimensiuni: 152 x 229 mm
Editura: ELSEVIER SCIENCE
ISBN-10: 0323991580
Pagini: 448
Dimensiuni: 152 x 229 mm
Editura: ELSEVIER SCIENCE
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Cuprins
Contributors
Short biographies of the contributors
Preface
1. General aspects of extracellular vesicles in bone formation and remodeling
Antonio Maurizi and Anna Teti
1. Introduction
2. Communications between bone cells
3. Extracellular vesicles
4. Bone cell overview
5. Bone marrow cells interacting with skeletal cells
6. Extracellular vesicle trafficking in the bone microenvironment
7. Extracellular vesicles in fracture healing
8. Extracellular vesicles and bone cancer
9. Medical applications
10. Conclusions
List of abbreviations
Acknowledgments
References
2. Physiological biomineralization. The properties and role of matrix vesicles in skeletal and dental calcifications
René Buchet, Saida Mebarek, Slawomir Pikula, Agnieszka Strzelecka-Kiliszek, David Magne, Leticia Fernanda Duffles, Thaise Mayumi Taira, Massimo Bottini, Pietro Ciancaglini, José Luis Millán and Sandra Yasuyo Fukada
1. Introduction
2. Biomineralization in teeth
3. Biomineralization in bones
4. Determinants of mineralization support the functions of matrix vesicles
5. Conclusions
List of abbreviations
Acknowledgments
References
3. Pathological biomineralization. Part I: mineralizing extracellular vesicles in cardiovascular diseases
Rene Buchet, Slawomir Pikula, Agnieszka Strzelecka-Kiliszek, Massimo Bottini, Ana Paula Ramos, Pietro Ciancaglini, Jose Luis Millan and Saida Mebarek
1. Introduction
2. Extracellular vesicles: origin and classification
3. Extracellular vesicles related to cardiovascular diseases
4. Extracellular vesicles: biomarkers of cardiovascular diseases
5. Extracellular vesicles as drug delivery vehicles in cardiovascular disease
6. Conclusions
List of abbreviations
Acknowledgments
References
4. Pathologic biomineralization: part II: mineralizing extracellular vesicles in osteoarthritis
Ann K. Rosenthal
1. Introduction
2. Historical perspective
3. Characterization of ACVs
4. ACVs from osteoarthritis cartilage
5. Factors affecting ACV mineralization
6. Conclusions and future directions
List of abbreviations
Acknowledgments
References
5. The biochemistry of mineralizing extracellular vesicles.
Part I: The role of phosphatases
Flavia Amadeu de Oliveira, Cintia Kazuko Tokuhara, Lucas Fabricio Bahia Nogueira, Juçara Gastaldi Cominal, Luiz Henrique da Silva Andrilli, Sonoko Narisawa, Colin Farquharson, Massimo Bottini, Ana Paula Ramos, Pietro Ciancaglini and José Luis Millán
1. Inorganic phosphate (Pi) and pyrophosphate (PPi): a physicochemical balance
2. The molecules regulating the Pi/PPi ratio
3. Tissue-nonspecific alkaline phosphatase
4. Ectonucleotide pyrophosphatase/phosphodiesterase 1 and other ENPPs
5. Nucleoside triphosphate diphosphohydrolase 1 (CD39) and ecto-50-nucleotidase (CD73)
6. PHOSPHO1
7. Can Na,K-ATPase act as a phosphatase?
8. Phosphate transporters
9. Genetic diseases caused by altered Pi/PPi ratio
10. Therapeutic approaches to normalizing the Pi/PPi ratio
11. Conclusions
List of abbreviations
Acknowledgments
References
6. The biochemistry of mineralizing extracellular vesicles.
Part II: Annexins 127
Slawomir Pikula, Agnieszka Strzelecka-Kiliszek, René Buchet, Saida Mebarek, Laurence Bessueille, Thierry Granjon, David Magne, Lilianna Weremiejczyk, Agnieszka Kinga Seliga and Joanna Bandorowicz-Pikula
1. Introduction
2. Annexins
3. Annexin knockout animal models
4. Annexins in mineralization-competent cells
5. Annexins in media vesicles and matrix vesicles
6. In vitro properties of annexins
7. Conclusions
List of abbreviations
Acknowledgments
References
7. Calcium and phosphate and their role in matrix vesicles: A biological view
Larwsk Hayann, Pietro Ciancaglini, Ana Paula Ramos and Dobrawa Napierala
1. Calcium (Ca2þ) and inorganic phosphate (PO3/4-/Pi) ions are essential for life
2. Ca2þ and phosphate ions in mineralization physiology and pathology
3. Cellular origins of matrix vesicles
4. Formation of mineralization-competent matrix vesicles requires osteo/chondrogenic molecular phenotype of the cells
5. Conclusions
List of abbreviations
Acknowledgments
References
8. Autophagy in bone metabolism and its possible role on the function of mineralizing extracellular vesicles
Marcos A.E. Cruz, Heitor G. Sebinelli, Pietro Ciancaglini, Massimo Bottini and Ana Paula Ramos
1. Molecular overview of autophagy
2. The canonical role of autophagy on bone maintenance
3. The noncanonical role of autophagy on bone mineralization
4. The role of autophagy on the release of mineralizing extracellular vesicles
5. Induced autophagy decreases smooth muscles cells calcification
6. Conclusions
List of abbreviations
Acknowledgments
References
9. The roles of mineralizing extracellular vesicles in cellecell communication
Tomoko Minamizaki, Shohei Kohono and Yuji Yoshiko
1. Introduction
2. Proteins in mineralizing EVs
3. miRNAs in mineralizing EVs
4. Conclusion
List of abbreviations
Acknowledgments
References
10. Working with mineralizing extracellular vesicles.
Part I: Purification techniques
René Buchet, Slawomir Pikula, Agnieszka Strzelecka-Kiliszek, David Magne, Massimo Bottini and Saida Mebarek
1. Discovery of matrix vesicles
2. Purification of matrix vesicles from the growth plates and epiphyseal cartilage of chicken embryos
3. Purification of matrix vesicles from rodent primary chondrocytes
4. Purification of matrix vesicles from osteoblast cell lines and from primary osteoblasts
5. Conclusion
List of abbreviations
Acknowledgments
References
11. Working with mineralizing extracellular vesicles.
Part II: Proteomic profiling
René Buchet, Saida Mebarek, Agnieszka Strzelecka-Kiliszek, Massimo Bottini and Slawomir Pikula
1. Introduction
2. Essential proteins found prior to the proteomic analysis
3. Proteomic analysis of matrix vesicles extracted from growth plate cartilage of chicken embryo
4. Proteomic analysis of matrix vesicles extracted from osteoblast cell lines
5. Comparative analysis of proteomes of matrix vesicles and articular cartilage vesicles
6. Comparative analysis of matrix vesicles and of extracellular vesicles proteomes
7. Conclusions
List of Abbreviations
Acknowledgments
References
12. Working with mineralizing extracellular vesicles.
Part III: The nucleational core
Ana Paula Ramos, Marcos Antonio Eufrasio Cruz, Pietro Ciancaglini, Saida Mebarek, René Buchet, José Luis Millan and Massimo Bottini
1. Introduction
2. Physicochemical aspects of biomineralization
3. Discovery of the nucleational core
4. Isolation and characterization of the nucleational core
5. Parameters driving the formation of phosphatidylserine complexes and amorphous calcium phosphate
6. Use of the AFM in the characterization of the nucleational core
7. Conclusions
List of abbreviations
Acknowledgments
References
13. Working with mineralizing extracellular vesicles
Part IV: Biomimetic models
Maytê Bolean, Heitor G. Sebinelli, Luiz H.S. Andrilli, Bruno Z. Favarin, Ekeveliny A. Veschi, Marcos A.E. Cruz, Rene Buchet, Saida Mebarek, José Luis Millán, Massimo Bottini, Ana Paula Ramos and Pietro Ciancaglini
1. Introduction
2. Proteoliposomes as biomimetic models to assess the role of TNAP in biomineralization
3. Proteoliposomes as biomimetic models to assess the role of Naþ,Kþ-ATPase and NPP1 in biomineralization
4. Proteoliposomes as biomimetic models to assess the role of annexins in biomineralization
5. Langmuir films as biomimetic models of matrix vesicles
6. Conclusions
List of abbreviations
Acknowledgments
References
14. Working with mineralizing extracellular vesicles.
Part V: Use of Mineralizing extracellular vesicles in bone regeneration
Larwsk Hayann, Maryanne Trafani Melo, Lucas Fabricio Bahia Nogueira, Pietro Ciancaglini, Massimo Bottini and Ana Paula Ramos
1. Introduction
2. Biogenesis of extracellular vesicles
3. Matrix vesicles: A special class of extracellular vesicles
4. Conclusions
List of abbreviations
Acknowledgments
References
Index
Short biographies of the contributors
Preface
1. General aspects of extracellular vesicles in bone formation and remodeling
Antonio Maurizi and Anna Teti
1. Introduction
2. Communications between bone cells
3. Extracellular vesicles
4. Bone cell overview
5. Bone marrow cells interacting with skeletal cells
6. Extracellular vesicle trafficking in the bone microenvironment
7. Extracellular vesicles in fracture healing
8. Extracellular vesicles and bone cancer
9. Medical applications
10. Conclusions
List of abbreviations
Acknowledgments
References
2. Physiological biomineralization. The properties and role of matrix vesicles in skeletal and dental calcifications
René Buchet, Saida Mebarek, Slawomir Pikula, Agnieszka Strzelecka-Kiliszek, David Magne, Leticia Fernanda Duffles, Thaise Mayumi Taira, Massimo Bottini, Pietro Ciancaglini, José Luis Millán and Sandra Yasuyo Fukada
1. Introduction
2. Biomineralization in teeth
3. Biomineralization in bones
4. Determinants of mineralization support the functions of matrix vesicles
5. Conclusions
List of abbreviations
Acknowledgments
References
3. Pathological biomineralization. Part I: mineralizing extracellular vesicles in cardiovascular diseases
Rene Buchet, Slawomir Pikula, Agnieszka Strzelecka-Kiliszek, Massimo Bottini, Ana Paula Ramos, Pietro Ciancaglini, Jose Luis Millan and Saida Mebarek
1. Introduction
2. Extracellular vesicles: origin and classification
3. Extracellular vesicles related to cardiovascular diseases
4. Extracellular vesicles: biomarkers of cardiovascular diseases
5. Extracellular vesicles as drug delivery vehicles in cardiovascular disease
6. Conclusions
List of abbreviations
Acknowledgments
References
4. Pathologic biomineralization: part II: mineralizing extracellular vesicles in osteoarthritis
Ann K. Rosenthal
1. Introduction
2. Historical perspective
3. Characterization of ACVs
4. ACVs from osteoarthritis cartilage
5. Factors affecting ACV mineralization
6. Conclusions and future directions
List of abbreviations
Acknowledgments
References
5. The biochemistry of mineralizing extracellular vesicles.
Part I: The role of phosphatases
Flavia Amadeu de Oliveira, Cintia Kazuko Tokuhara, Lucas Fabricio Bahia Nogueira, Juçara Gastaldi Cominal, Luiz Henrique da Silva Andrilli, Sonoko Narisawa, Colin Farquharson, Massimo Bottini, Ana Paula Ramos, Pietro Ciancaglini and José Luis Millán
1. Inorganic phosphate (Pi) and pyrophosphate (PPi): a physicochemical balance
2. The molecules regulating the Pi/PPi ratio
3. Tissue-nonspecific alkaline phosphatase
4. Ectonucleotide pyrophosphatase/phosphodiesterase 1 and other ENPPs
5. Nucleoside triphosphate diphosphohydrolase 1 (CD39) and ecto-50-nucleotidase (CD73)
6. PHOSPHO1
7. Can Na,K-ATPase act as a phosphatase?
8. Phosphate transporters
9. Genetic diseases caused by altered Pi/PPi ratio
10. Therapeutic approaches to normalizing the Pi/PPi ratio
11. Conclusions
List of abbreviations
Acknowledgments
References
6. The biochemistry of mineralizing extracellular vesicles.
Part II: Annexins 127
Slawomir Pikula, Agnieszka Strzelecka-Kiliszek, René Buchet, Saida Mebarek, Laurence Bessueille, Thierry Granjon, David Magne, Lilianna Weremiejczyk, Agnieszka Kinga Seliga and Joanna Bandorowicz-Pikula
1. Introduction
2. Annexins
3. Annexin knockout animal models
4. Annexins in mineralization-competent cells
5. Annexins in media vesicles and matrix vesicles
6. In vitro properties of annexins
7. Conclusions
List of abbreviations
Acknowledgments
References
7. Calcium and phosphate and their role in matrix vesicles: A biological view
Larwsk Hayann, Pietro Ciancaglini, Ana Paula Ramos and Dobrawa Napierala
1. Calcium (Ca2þ) and inorganic phosphate (PO3/4-/Pi) ions are essential for life
2. Ca2þ and phosphate ions in mineralization physiology and pathology
3. Cellular origins of matrix vesicles
4. Formation of mineralization-competent matrix vesicles requires osteo/chondrogenic molecular phenotype of the cells
5. Conclusions
List of abbreviations
Acknowledgments
References
8. Autophagy in bone metabolism and its possible role on the function of mineralizing extracellular vesicles
Marcos A.E. Cruz, Heitor G. Sebinelli, Pietro Ciancaglini, Massimo Bottini and Ana Paula Ramos
1. Molecular overview of autophagy
2. The canonical role of autophagy on bone maintenance
3. The noncanonical role of autophagy on bone mineralization
4. The role of autophagy on the release of mineralizing extracellular vesicles
5. Induced autophagy decreases smooth muscles cells calcification
6. Conclusions
List of abbreviations
Acknowledgments
References
9. The roles of mineralizing extracellular vesicles in cellecell communication
Tomoko Minamizaki, Shohei Kohono and Yuji Yoshiko
1. Introduction
2. Proteins in mineralizing EVs
3. miRNAs in mineralizing EVs
4. Conclusion
List of abbreviations
Acknowledgments
References
10. Working with mineralizing extracellular vesicles.
Part I: Purification techniques
René Buchet, Slawomir Pikula, Agnieszka Strzelecka-Kiliszek, David Magne, Massimo Bottini and Saida Mebarek
1. Discovery of matrix vesicles
2. Purification of matrix vesicles from the growth plates and epiphyseal cartilage of chicken embryos
3. Purification of matrix vesicles from rodent primary chondrocytes
4. Purification of matrix vesicles from osteoblast cell lines and from primary osteoblasts
5. Conclusion
List of abbreviations
Acknowledgments
References
11. Working with mineralizing extracellular vesicles.
Part II: Proteomic profiling
René Buchet, Saida Mebarek, Agnieszka Strzelecka-Kiliszek, Massimo Bottini and Slawomir Pikula
1. Introduction
2. Essential proteins found prior to the proteomic analysis
3. Proteomic analysis of matrix vesicles extracted from growth plate cartilage of chicken embryo
4. Proteomic analysis of matrix vesicles extracted from osteoblast cell lines
5. Comparative analysis of proteomes of matrix vesicles and articular cartilage vesicles
6. Comparative analysis of matrix vesicles and of extracellular vesicles proteomes
7. Conclusions
List of Abbreviations
Acknowledgments
References
12. Working with mineralizing extracellular vesicles.
Part III: The nucleational core
Ana Paula Ramos, Marcos Antonio Eufrasio Cruz, Pietro Ciancaglini, Saida Mebarek, René Buchet, José Luis Millan and Massimo Bottini
1. Introduction
2. Physicochemical aspects of biomineralization
3. Discovery of the nucleational core
4. Isolation and characterization of the nucleational core
5. Parameters driving the formation of phosphatidylserine complexes and amorphous calcium phosphate
6. Use of the AFM in the characterization of the nucleational core
7. Conclusions
List of abbreviations
Acknowledgments
References
13. Working with mineralizing extracellular vesicles
Part IV: Biomimetic models
Maytê Bolean, Heitor G. Sebinelli, Luiz H.S. Andrilli, Bruno Z. Favarin, Ekeveliny A. Veschi, Marcos A.E. Cruz, Rene Buchet, Saida Mebarek, José Luis Millán, Massimo Bottini, Ana Paula Ramos and Pietro Ciancaglini
1. Introduction
2. Proteoliposomes as biomimetic models to assess the role of TNAP in biomineralization
3. Proteoliposomes as biomimetic models to assess the role of Naþ,Kþ-ATPase and NPP1 in biomineralization
4. Proteoliposomes as biomimetic models to assess the role of annexins in biomineralization
5. Langmuir films as biomimetic models of matrix vesicles
6. Conclusions
List of abbreviations
Acknowledgments
References
14. Working with mineralizing extracellular vesicles.
Part V: Use of Mineralizing extracellular vesicles in bone regeneration
Larwsk Hayann, Maryanne Trafani Melo, Lucas Fabricio Bahia Nogueira, Pietro Ciancaglini, Massimo Bottini and Ana Paula Ramos
1. Introduction
2. Biogenesis of extracellular vesicles
3. Matrix vesicles: A special class of extracellular vesicles
4. Conclusions
List of abbreviations
Acknowledgments
References
Index
Recenzii
"...focuses on the often-overlooked process of biomineralization, which depends on extracellular vesicles to serve as vehicles for conveying inorganic materials to the sites of biomineralization in the body.... [T]he first comprehensive and up-to-date resource covering all aspects of mineralizing extracellular vesicles, from composition and function to pathophysiology and clinical potential.... [A]kin to an encyclopedic resource,... written in a clear, direct, and economical manner that students will find preferable to the parade of long, grammatically complex sentences that often dominate technical writing. The book is concise and contents well-organized,... contains a generous list of references, which contain a weblinks for easy access. [A] well-written book that is particularly well-suited for college, graduate, and professional students. Given the biomedical significance of its subject matter, comprehensive coverage, and clarity of presentation, it represents a particularly valuable resource for a biomedical library." --©Doody’s Review Service, 2024, Peter J. Kennelly, PhD (Virginia Tech)