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Moyamoya Disease Explored Through RNF213: Genetics, Molecular Pathology, and Clinical Sciences de Akio Koizumi

Moyamoya Disease Explored Through RNF213: Genetics, Molecular Pathology, and Clinical Sciences: Current Topics in Environmental Health and Preventive Medicine

Editat de Akio Koizumi, Kazuhiro Nagata, Kiyohiro Houkin, Teiji Tominaga, Susumu Miyamoto, Shigeo Kure, Elizabeth Tournier-Lasserve
en Limba Engleză Paperback – 7 aug 2018
This book presents the latest findings on biological, epidemiological, and clinical investigations of RNF213, which is thought to be involved in many biological processes and plays a key role in cerebro- and cardiovascular disease . By discussing the epidemiology and genetic epidemiology of the disease with a particular focus on the molecular function of RNF213, research using animal models, diagnosis, therapy and clinical management around the world, this work makes a valuable contribution to the study of the disease.
Moyamoya Disease Explored Through RNF213 is an indispensable resource for both beginning and experienced researchers, pediatricians, neurologists, and neurosurgeons who are seeking comprehensive information on adult and childhood stroke.
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Specificații

ISBN-13: 9789811096891
ISBN-10: 9811096899
Pagini: 185
Ilustrații: VIII, 185 p. 36 illus., 22 illus. in color.
Dimensiuni: 155 x 235 x 18 mm
Ediția:Softcover reprint of the original 1st ed. 2017
Editura: Springer Nature Singapore
Colecția Springer
Seria Current Topics in Environmental Health and Preventive Medicine

Locul publicării:Singapore, Singapore

Cuprins

Part I: Prologue.-
1. A prologue to moyamoya disease and RNF213.-
2. Concept of moyamoya Disease.-

Part II: Genetic Epidemiology.-
3. Molecular Epidemiology in East Asian Countries and in the World.-

Part III: Biochemistry, Function and Molecular Pathology.-
4. Molecular Biology of Mysterin/RNF213.-
5. Physiological Role of Mysterin/RNF213 in Zebrafish.-
6. Pathological Investigation on RNF213: Animal Models Knockout and Transgenic Mice in Diabetes and Signal Transduction.-
7. Pathological Investigation on RNF213: Animal Models of Rnf213-knockout and Knock-in Mice.-
8. RNF213 and Circulating Factors in Patients with Moyamoya Disease .-
9. Genetics of Moyamoya beyond RNF213.  Monogenic Moyamoya Syndromes.-

Part IV: Clinical Management
10. Natural History and Long-term Clinical Outcome after Conservative and Surgical Management.-
11. Significance of RNF213 in Clinical Management in Japan.-
12. Significance of RNF213 in Clinical Management in China.-
13. The Different Forms of Moyamoya Disease and Their Clinical Management.-
14. Vascular Diseases Attributable to RNF213 Other than Moyamoya Disease.-

Part V: Epilogue.-
Future Clinical Perspectives on RNF213 in Moyamoya Disease.

Notă biografică

Akio Koizumi, Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University

Kazuhiro Nagata, Laboratory of Molecular and Cellular biology, Faculty of Life Sciences, Kyoto Sangyo University

Kiyohiro Houkin, Department of Neurosurgery, Graduate School of Medicine, Hokkaido University

Teiji Tominaga, Department of Neurosurgery, Tohoku University School of Medicine 

Susumu Miyamoto, Department of Neurosurgery, Graduate School of Medicine, Kyoto University

Shigeo Kure, Department of Pediatrics, Tohoku University School of Medicine

Elizabeth Tournier‐Lasserve, CHU Paris‐GH St‐Louis Lariboisière F‐Widal ‐ Hôpital Lariboisière




Textul de pe ultima copertă

This book presents the latest findings on biological, epidemiological, and clinical investigations of RNF213, which is thought to be involved in many biological processes and plays a key role in cerebro- and cardiovascular disease . By discussing the epidemiology and genetic epidemiology of the disease with a particular focus on the molecular function of RNF213, research using animal models, diagnosis, therapy and clinical management around the world, this work makes a valuable contribution to the study of the disease.
Moyamoya Disease Explored Through RNF213 is an indispensable resource for both beginning and experienced researchers, pediatricians, neurologists, and neurosurgeons who are seeking comprehensive information on adult and childhood stroke.

Caracteristici

Presents the latest findings on biological, epidemiological and clinical investigations of RNF213 Provides information on the epidemiology and genetic epidemiology of moyamoya disease Offers a valuable resource for both beginning and experienced researchers, as well as pediatricians, neurologists, and neurosurgeons