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Neurotrophic Factors de Gary R. Lewin

Neurotrophic Factors: Handbook of Experimental Pharmacology, cartea 220

Editat de Gary R. Lewin, Bruce D. Carter
en Limba Engleză Hardback – 8 apr 2014
This book provides critical reviews of the role of neurotrophins and their receptors in a wide variety of diseases including neurodegenerative diseases like Huntington’s syndrome, cognitive function, psychiatric disorders such as clinical depression, Rett syndrome, motoneurone disease, spinal cord injury, pain, metabolic disease and cardiovascular disease. It also contains contributions from leaders in the field dealing with the basic biology, transcriptional and post-translational regulation of the neurotrophins and their receptors. The present book will review all recent areas of progress in the study of neurotrophins and their biological roles.
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Specificații

ISBN-13: 9783642451058
ISBN-10: 3642451055
Pagini: 520
Ilustrații: VIII, 520 p. 37 illus., 27 illus. in color.
Dimensiuni: 155 x 235 x 27 mm
Greutate: 1.16 kg
Ediția:2014
Editura: Springer Berlin, Heidelberg
Colecția Springer
Seria Handbook of Experimental Pharmacology

Locul publicării:Berlin, Heidelberg, Germany

Public țintă

Research

Cuprins

The Neurotrophin Family: NGF, BDNF, NT3 and NT4.- Deciphering Proneurotrophin Actions.- Spatio-Temporal Intracellular Dynamics of Neurotrophins and Their Receptors. Implications for Neurotrophin Signaling and Neuronal Function.- Neurotrophins: Transcription and Translation.- Neurotrophin Receptors: Trk Receptors.- The Biological Functions and Signaling Mechanisms of the p75 Neurotrophin Receptor.- Sortilins in Neurotrophic Factor Signaling.- The Biology of Neurotrophins: Neurotrophins in the Regulation of Cellular Survival and Death.- BDNF and Synaptic Plasticity, Cognitive Function and Dysfunction.- Nerve Growth Factor and Nociception: From Experimental Embryology to New Analgesic Therapy.- Neurotrophins and the Regulation of Energy Balance and Body Weight.- The Biology of Neurotrophins: Cardiovascular Function.- Neurotrophin signalling and transcription programs interactions in the development of somatosensory neurons.- Neurotrophins in Pathological Conditions: Huntington’s Disease.- Motoneuron Disease.- Neurotrophic Factors in Spinal Cord Injury.- Neurotrophins and Psychiatric Disorders.- Brain Derived Neurotrophic Factor and Rett Syndrome.- Modulation of Neurotrophin Signaling by Monoclonal Antibodies.

Caracteristici

The relevance of neurotrophins in a variety of diseases ranging from inflammatory pain, to neurodegeneration and metabolic disease is comprehensively reviewed The successful pharmacological avenues used for manipulating neurotrophin signalling in disease as well as future perspectives for their modulation is extensively reviewed World renowned experts are revealing future perspectives for new therapies based on neurotrophin signalling and their downstream targets Includes supplementary material: sn.pub/extras