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Pharmacology of Mitochondria de Harpreet Singh

Pharmacology of Mitochondria: Handbook of Experimental Pharmacology, cartea 240

Editat de Harpreet Singh, Shey-Shing Sheu
en Limba Engleză Paperback – 10 aug 2018
This special book is conceived to highlight mitochondrial structural and functional integrity and how they are associated with several human diseases such as cardiovascular, cancer, renal, neurological disorder, and genetic disorders. The chapters contributed by leading mitochondrial researchers in the handbook will take us through the novel pharmacological strategies via mitochondria to understand their physiological and pathological role as well as present them as therapeutic targets.
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Specificații

ISBN-13: 9783319861302
ISBN-10: 3319861301
Pagini: 493
Ilustrații: XI, 493 p.
Dimensiuni: 155 x 235 mm
Ediția:Softcover reprint of the original 1st ed. 2017
Editura: Springer International Publishing
Colecția Springer
Seria Handbook of Experimental Pharmacology

Locul publicării:Cham, Switzerland

Cuprins

Mitochondrial Genetics and Ion Transportation: Nuclear transcription factors in the mitochondria: a new paradigm in cellular transformation.- The mitochondrial permeability transition pore and ATP synthase.- Mitochondrial ion fluxes in health and diseases.- Mitochondrial anion channels.- Pharmacology of mitochondrial potassium channels.- Mitochondrial Ca2+ uniporter complex as promising therapeutic target for human diseases and aging.- Mitochondria in Health and Diseases: Mitochondrial Division in Human Disease.- Mitochondrial cholesterol and the paradox in cell death.- Mitochondrial dysfunction in neuromuscular disorders.- Mitochondrial dynamics in cancer.- The emerging role of mitochondrial targeting in kidney disease.- Mitochondrial dynamics as therapeutic targets for treating cardiac disease.- Mitochondria in Alzheimer´s disease and Diabetes-associated Neurodegeneration.- Leber Hereditary Optic Neuropathy, a mitochondrial disease unique in many ways.- Therapeutic Approaches and Mitochondria: Mitochondrial Variation in Health and Disease.- Bioinformatic methods and resources for integrated mitochondrial physiology.- Nanoparticle based therapeutics for mitochondrial dysfunctions.- Mitochondrial respiratory chain complexes as drugs targets.- Targeting the Mitoflash for the Control of Mitochondrial Functions.-Mitochondrial Antioxidant Therapy: Promise or Delusion?- Roles of mitochondrial ROS generation to protect from further prooxidant situations.- MITO-Porter for mitochondrial delivery and mitochondrial functional analysis.- Toxicity of antiepileptic drugs to mitochondria.

Caracteristici

First book in the HEP series on pharmacology of mitochondria, in which vast number of current topics pertaining to mitochondria will be presented Unique methods to study mitochondria are covered, such as super resolution microscopy, nano particles, proteomics, calcium and ROS measurements Drug development specifically to mitochondria will be extensively discussed Includes supplementary material: sn.pub/extras Includes supplementary material: sn.pub/extras