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Principles and Practice of Bioanalysis

Editat de Richard F. Venn
en Limba Engleză Paperback – 22 iun 2000
Principles and Practice of Bioanalysis provides a guide to the methods available and the techniques currently used in this field. It provides up to the minute information and guidance on the methods and strategy used in developing and running ultra-trace analyses for drugs, metabolites and other substances. The authors writes in an informal and didactic style, offering a logical path through the problems of small molecule (bio)analysis and enables readers to choose appropriate methods of analysis for their needs. Principles and Practice of Bioanalysis provides an overview of analytical methods for analytical scientists within the pharmaceutical industry, research and development, the agrochemical industry, and scientists in the health service, biology and biochemistry. It also gives postgraduate students a useful reference for their research methods.
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Specificații

ISBN-13: 9780748408436
ISBN-10: 0748408436
Pagini: 382
Ilustrații: 125 tables
Dimensiuni: 178 x 254 x 24 mm
Greutate: 0.71 kg
Ediția:1
Editura: CRC Press
Colecția CRC Press
Locul publicării:Boca Raton, United States

Public țintă

Academic, Professional Practice & Development, Professional Reference, and Undergraduate

Cuprins

1. Physico-chemical properties of drugs and metabolites and their extraction from biological material Hugh Wiltshire 2. Solid phase extraction Chris James 3. Basic HPLC theory and practice Andy Gray 4. HPLC optimisation David Bakes 5. HPLC detectors Richard Venn 6. Gas chromotography-what it is and how we use it Peter Andrew 7. Thin layer chromotography Hugh Wiltshire 8. Capillary electrophoresis Peter Andrew 9. Immunoassay techniques Richard Venn 10. Automation of sample preparation Chris James 11. Fundamental aspects of mass spectrometry "overview terminology" Mira V. Doig 12. Applications of mass spectrometry: quantitative mass spectrometry Mira V. Doig 13. Mass spectrometric identification of metabolites Janet Oxford 14. Nuclear magnetic resonance in drug metabolism Phil Gilbert 15. Strategy in metabolite isolation and identification Hugh Wiltshire 16. Strategy for the development of quantitative analytical procedures David Bakes Pharmacia & Upjohn, UK, Andy Gray, Astra Charnwood, UK, David Bakes, Servier Research & Development Ltd., UK, Richard F. Venn, Pfizer Central Research, UK, Peter Andrew, GlaxoWellcome, UK, Mira V. Doig, Advanced Bioanalytical Laboratories, UK, Janet Oxford, SmithKline Beecham, UK, Phil Gilbert, Chiroscience, UK.

Descriere

Written in an informally pedagogical style, this book provides comprehensive information and guidance on the methods and strategies used in developing and running ultra-trace analyses for drugs, metabolites, and other substances. It presents a logical path through the problems of small-molecule bionalaysis and helps readers choose methods of analysis appropriate for their needs. Although not a laboratory manual of recipes, the book contains sufficient references that allow readers to find relevant literature material quickly. It gives undergraduates a useful overview of analytical methods and postgraduate students sharper research methods.

Recenzii

"The book consists of 15 chapters written by internationally distinguished experts from biotech and pharmacological companies, mostly located in United Kingdom…. Each chapter contains a bibliography of the most important papers in each field discussed in the book. This book is quite valuable theoretically and methodologically for specialists of various fields of analytical chemistry and biochemistry, molecular biology, and biotechnology. I believe that this book will become an important desk book for researchers working with bioanalysis of various drugs and metabolites."
—G. Ya. Wiederschain, Doctor of Biological Sciences, in Biochemistry, 2008, Vol. 73, No. 12
 
"… a living guide on the subject, scrutinizing how its topics have changed over the years – mass spectronomy, immunoassay, gas chromatography and more. A scholarly, seminal piece, Principles and Practices of Bioanalysis is highly recommended for community library science collections."
– James A. Cox and Diane C. Donovan in Midwest Book Review, 2008
"I found it instructive and interesting – an adjective that unfortunately can only be applied to textbooks relatively infrequently!"
– E. R. Adlard, in Chromatographia, July 2008, Vol. 68, No. 1/2