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Protein Quality Control in Neurodegenerative Diseases: Research and Perspectives in Alzheimer's Disease

Editat de Richard I. Morimoto, Yves Christen
en Limba Engleză Paperback – 29 ian 2015
The health of the proteome depends upon protein quality control to regulate the proper synthesis, folding, translocation, and clearance of proteins. The cell is challenged constantly by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded proteins. Substantial evidence supports the hypothesis that the expression of damaged proteins initiates a cascade of molecular events that leads to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and other diseases of protein conformation.
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Specificații

ISBN-13: 9783642447068
ISBN-10: 3642447066
Pagini: 136
Ilustrații: XII, 136 p.
Dimensiuni: 155 x 235 x 8 mm
Greutate: 0.22 kg
Ediția:2013
Editura: Springer Berlin, Heidelberg
Colecția Springer
Seria Research and Perspectives in Alzheimer's Disease

Locul publicării:Berlin, Heidelberg, Germany

Public țintă

Research

Cuprins

The Regulation and Function of the Heat Shock Response by Eric Guisbert and Richard I. Morimoto.- The Endoplasmic Reticulum Unfolded Protein Response and Neurodegeneration by David Ron.- Proteostasis and the aging pathways by Ian Nicastro and Andrew Dillin.- The Membrane Sources of Macroautophagy by Daniel J. Klionsky, Melinda A. Lynch-Day, Jiefei Geng, and Wei-Lien Yen.- Selective Autophagy in Cellular Quality Control by Susmita Kaushik and Ana Maria Cuervo.- Quality Control of Proteins and Organelles by Autophagy by Noboru Mizushima.- The Role of the Co-Chaperone BAG3 in Selective Macroautophagy: Implications for Aging and Disease by Christian Behl.- Predicting Fates in Models of Neurodegenerative Disease: Longitudinal Measures of Protein Homeostasis in Live Neurons by Steven Finkbeiner.- Therapeutic Potential of Longevity Modulators as Neuroprotective Targets in Neurodegenerative Disease by Rafael Vazquez-Manrique, Cendrine Tourette and Christian Neri.- Subject code.

Recenzii

From the reviews:
“This is a very good cutting edge book of scholarly import on the functioning of molecules and signal transduction in both neurodegeneration and neuroprotection. … I recommend this book highly to scientists in disease pathophysiology work.” (Joseph J. Grenier, Amazon.com, June, 2014)

Textul de pe ultima copertă

The health of the proteome depends upon protein quality control to regulate the proper synthesis, folding., translocation, and clearance of proteins. The cell is challenged constantyl by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded proteins. Substantial evidence supports the hypothesis that the expression of damaged proteins initiates a cascade of molecular events that leads to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and other diseases of protein conformation.

Caracteristici

Written by leading experts in the fields Neuroscience and Endocrinology Provides topical research results Another excellent group of authors and their chapters collected by Fondation Ipsen Includes supplementary material: sn.pub/extras