Structure-Based Drug Design (NATO Science Series E:) de P.W. Codding

Structure-Based Drug Design: Experimental and Computational Approaches: NATO Science Series E:, cartea 352

P.W. Codding

Structure-Based Drug Design brings together scientists working on different aspects of the subject, demonstrating the necessary collaboration and interdisciplinary approach to this complex area. The focus is on X-ray crystallographic and computational approaches. The general aspects of these approaches are introduced in the first six articles. The remaining articles provide examples of the application of X-ray crystallography, molecular modelling, molecular dynamics, QSAR, database analysis, and homology modelling. The papers cover a wealth of interesting problems in the design of new and enhanced pharmaceuticals.

Citește tot Restrânge

	Preț	Express
Paperback (1)	944^.67 lei 6-8 săpt.
SPRINGER NETHERLANDS – 9 dec 2010	944^.67 lei 6-8 săpt.
Hardback (1)	950^.66 lei 6-8 săpt.
SPRINGER NETHERLANDS – 31 aug 1998	950^.66 lei 6-8 săpt.

Preț

Express

Paperback (1)

944^.67 lei 6-8 săpt.

SPRINGER NETHERLANDS – 9 dec 2010

944^.67 lei 6-8 săpt.

Hardback (1)

950^.66 lei 6-8 săpt.

SPRINGER NETHERLANDS – 31 aug 1998

950^.66 lei 6-8 săpt.

Din seria NATO Science Series E:

24%

Preț: 1570^.65 lei
Preț: 397^.76 lei
Preț: 386^.81 lei
20%

Preț: 346^.24 lei
Preț: 424^.33 lei
18%

Preț: 1224^.18 lei
18%

Preț: 1836^.63 lei
18%

Preț: 1229^.28 lei
Preț: 381^.00 lei
Preț: 409^.30 lei
18%

Preț: 1841^.36 lei
5%

Preț: 367^.28 lei
Preț: 407^.19 lei
18%

Preț: 1838^.38 lei
Preț: 420^.28 lei
Preț: 399^.29 lei
Preț: 398^.74 lei
18%

Preț: 3026^.13 lei
Preț: 388^.90 lei
5%

Preț: 391^.06 lei
18%

Preț: 1228^.62 lei
18%

Preț: 1229^.73 lei
18%

Preț: 1234^.46 lei
5%

Preț: 3532^.05 lei
18%

Preț: 1840^.11 lei
5%

Preț: 378^.80 lei
18%

Preț: 1227^.84 lei
Preț: 392^.75 lei
Preț: 395^.63 lei
18%

Preț: 2489^.30 lei
5%

Preț: 1429^.27 lei
Preț: 396^.02 lei
5%

Preț: 2142^.61 lei
18%

Preț: 3049^.16 lei
18%

Preț: 1844^.54 lei
Preț: 403^.53 lei

Cuprins

Steroid Hormone Structure, Receptor Binding and Activity: Empirical Drug Design.- The Cambridge Structural Database System: Conformational Analysis from Crystallographic Data.- SAR, Scope and Limitations of Molecular Design Approaches.- Computational Strategies for Modeling Receptor Flexibility in Studies of Receptor-Ligand Interactions.- Application of Machine Learning in Drug Design.- 3D Molecular Similarity Methods: In Search of a Pharmacophore.- Collagenase and Family: Targets for Drug Design.- Drugs Targeting Influenza Virus Neuraminidase.- From Cyclohexane to FK506 — Conformational Analysis by Molecular Dynamics.- The Use of Uncoded ?-Amino Acids Residues in Drug Design.- Use of the Cambridge Structural Database to Study Non-Covalent Interactions: Towards a Knowledge Base of Intermolecular Interactions.- Immunoconjugates as Anti-Cancer Agents.- Database Searching using Protein Crystal Structures and Molecular Docking Procedures.- Recent Developments in Applying Machine Learning to Drug Design.- Structure-Based Design of Novel Heparin-like Anticoagulants.- Structure, Mechanism of Action and Inhibition of Dehydrogenase Enzymes.- In Search of Hypoglycaemic Agents for the Treatment of Non-Insulin Dependent Diabetes Mellitus.- 3D Molecular Similarity Methods: Application to Modeling HIV-1 Reverse Transcriptase Inhibitor Binding.- Computational Approaches to Modeling Receptor Flexibility upon Ligand Binding: Application to Interfacially Activated Enzymes.- Exploring Drug Design Methods with Thymidylate Synthase.- Computational Tools for Structure-Based Drug Design.- Antibody-Antigen Interactions — Lessons in Molecular Design.- Antibacterial Design Based on the Structures of Gyrase-Inhibitor Complexes.- Integrated Homology Modelling and X-ray Study of Herpes SimplexVirus I Thymidine Kinase.