The book presents an avant-garde and interdisciplinary technical-entrepreneurial approach for ensuring sustainability by bringing a Systems Engineering (SE) novel mechanism applied to telemedicine context making use of space technologies into the light. The distinctive theory from herein incorporates the international expertise of the author, Cristian Vizitiu, on SE and entrepreneurship within space field. This book targets a comprehensive SE technical solution, enriched with knowledge management & entrepreneurial assessment psychometric instruments for Corporate Entrepreneurship (CE) stimulation, to achieve sustainable services based on user-centered approach.