Telomeres and Telomerase in Cancer: Cancer Drug Discovery and Development
Editat de Keiko Hiyamaen Limba Engleză Paperback – 19 noi 2010
Toate formatele și edițiile | Preț | Express |
---|---|---|
Paperback (1) | 1338.83 lei 6-8 săpt. | |
Humana Press Inc. – 19 noi 2010 | 1338.83 lei 6-8 săpt. | |
Hardback (1) | 1316.74 lei 38-44 zile | |
Humana Press Inc. – 27 feb 2009 | 1316.74 lei 38-44 zile |
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Specificații
ISBN-13: 9781617378881
ISBN-10: 1617378887
Pagini: 380
Ilustrații: XII, 380 p. 60 illus., 19 illus. in color.
Dimensiuni: 155 x 235 x 20 mm
Greutate: 0.54 kg
Ediția:Softcover reprint of hardcover 1st ed. 2009
Editura: Humana Press Inc.
Colecția Humana
Seria Cancer Drug Discovery and Development
Locul publicării:Totowa, NJ, United States
ISBN-10: 1617378887
Pagini: 380
Ilustrații: XII, 380 p. 60 illus., 19 illus. in color.
Dimensiuni: 155 x 235 x 20 mm
Greutate: 0.54 kg
Ediția:Softcover reprint of hardcover 1st ed. 2009
Editura: Humana Press Inc.
Colecția Humana
Seria Cancer Drug Discovery and Development
Locul publicării:Totowa, NJ, United States
Public țintă
Professional/practitionerCuprins
Basic Background.- Telomeres and Telomerase in Humans.- Telomere-Binding Proteins in Humans.- Regulation of Telomerase Through Transcriptional and Posttranslational Mechanisms.- Telomere Dysfunction and the DNA Damage Response.- Alternative Lengthening of Telomeres in Human Cells.- Mouse Model: Telomeres and Telomerase in Stem Cell and Cancer.- Telomeres and Telomerase in Human Cancers.- Role of Telomeres and Telomerase in Cancer.- Diagnostic Value I: Solid Tumors.- Diagnostic Value II: Hematopoietic Malignancies.- Therapeutic Targets and Drugs I: Telomerase and Telomerase Inhibitors.- Therapeutic Targets and Drugs II: G-Quadruplex and G-Quadruplex Inhibitors.- Therapeutic Targets and Drugs III: Tankyrase 1, Telomere-Binding Proteins, and Inhibitors.- Therapeutic Targets and Drugs IV: Telomerase-Specific Gene and Vector-Based Therapies for Human Cancer.- Experimental Protocols.- Protocol I: Telomerase Activity and Telomerase Expression.- Protocol II: Importance and Methods of Telomere G-Tail Length Quantification.- Protocol III: Detection of Alternative Lengthening of Telomeres.
Textul de pe ultima copertă
Telomeres and telomerase are the pivotal players that destine cellular senescence and immortalization. Telomere shortening due to "End-replication problem" in each cell cycle is a universal phenomenon for all eukaryotic cells with linear chromosomes. Its compensation by telomerase is also common from yeast to human. However, the length of telomeres, distribution of telomerase positive cells, and consequence of telomerase inhibition are different among species. "Telomeres and Telomerase in Cancers", edited by Keiko Hiyama, focuses on "Human" telomeres and telomerase, from basic biology and hypothesis in human normal cells and cancer cells to clinical application as diagnostic tools and therapeutic targets in anti-cancer strategy. Cutting-edge experimental protocols for their evaluation are also included. This coverage will enable medical oncologists and students as well as basic researchers to capture the up-to-date entire picture of human telomeres and telomerase in cancer.
Caracteristici
This book will focus on telomere and telomerase in human cancers and may provide medical doctors, pathologists, and translational cancer researchers with a deep understanding of these unique and fascinating molecules, as well as hot topics in clinical applications