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The Neuropharmacology of Alcohol de Kathleen A. Grant

The Neuropharmacology of Alcohol: Handbook of Experimental Pharmacology, cartea 248

Editat de Kathleen A. Grant, David M. Lovinger
en Limba Engleză Hardback – 8 apr 2019
This volume gives an overview of new insights to alcohol pharmacology using DREADDs (Designer Receptors and Unraveling the Neuropharmacology of Alcohol). It examines which pharmacological principles should be applied to understanding DREADDs taking into account some very current research. Additionally, this book covers important topics under the heading of “experimental pharmacology” and alcohol.
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Specificații

ISBN-13: 9783319965222
ISBN-10: 3319965220
Pagini: 592
Ilustrații: XI, 625 p. 36 illus., 32 illus. in color.
Dimensiuni: 155 x 235 x 42 mm
Greutate: 1.07 kg
Ediția:1st ed. 2018
Editura: Springer International Publishing
Colecția Springer
Seria Handbook of Experimental Pharmacology

Locul publicării:Cham, Switzerland

Cuprins

Part 1. Neurotransmitter systems.- 1. GABAA receptor subtype mechanism and the abuse related effects of ethanol: Genetic and pharmacological evidence.- 2. Presynaptic Ethanol Actions: Potential Roles in Ethanol Seeking.- 3. Dynamic adaptation in neurosteroid networks in response to alcohol.- 4. GABA and Glutamate synaptic co-adaptations to chronic ethanol in the striatum.- 5. The cerebellar GABAAR system as a potential target for treating alcohol use disorder.- 6. Do alcohol-related AMPA-type glutamate receptor adaptations promote intake?.- 7. Molecular, neuronal and behavioral effects of ethanol and nicotine interactions.- 8. Cross-species alterations in synaptic dopamine regulation after chronic alcohol exposure.- 9.Central noradrenergic interactions with alcohol and regulation of alcohol related behaviors.- Part 2. Ion Channels.- 10. Voltage-sensitive calcium channels in the brain: Relevance to alcohol intoxication and withdrawal.- 11. Voltage-sensitive potassium channels of the BK type and their coding genes are alcohol targets in neurons.- 12. Chronic alcohol, intrinsic excitability, and potassium channels: Neuroadaptations and drinking behavior.- Part 3. Neuroimmune system.- 13. Hepatic immune system adaptations to alcohol.- 14. Innate immune signaling and alcohol use disorders.- 15.Cytokins in the CNS.- Part 4. Neuropeptides and Genomics.- 16. Corticotropin Releasing Factor (CRF) Neurocircuitry and neuropharmacology in alcohol drinking.- 17. Contribution of dynorphin and orexin neuropeptide systems to the motivational effects of alcohol.- 18. Transcriptional regulators as targets for alcohol pharmacotherapies.- Part 5. Pharmacotherapy.- 19. Advances in Pharmacotherapy Development From Preclinical Animal Studies.- 20. Advances in Pharmacotherapy Development: Human Clinical Studies.

Caracteristici

Provides new insights to alcohol pharmacology using DREADDs Discusses latest techniques that are utilized in the circuitry field Includes very current research extending to the clinic