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The Nucleolus de Mark O. J. Olson

The Nucleolus: Molecular Biology Intelligence Unit

Editat de Mark O. J. Olson
en Limba Engleză Hardback – 3 aug 2004
As the first comprehensive overview of the nucleolus since 1985, The Nucleolus covers our current understanding of the cell nucleolus, including its role in ribosome assembly and its additional newly-discovered activities. The eighteen chapters have been written by experts who are actively engaged in research on the nucleolus and have an in depth review of the following topics: - nucleolar ultrastructure and dynamics,
- behavior during mitosis,
- ribosomal DNA gene and chromatin structure,
- pre-ribosomal RNA transcription,
- processing and modification,
- ribosome assembly,
- small nucleolar RNAs,
- proteomics and non-traditional functions of the nucleolus.
Separate chapters are also provided for yeast and higher eukaryotes on many topics.
The Nucleolus will appeal not only to scientists directly engaged in nucleolar research, but also those working in related areas such as gene expression, protein biosynthesis, ribosome structure, transcription, chromatin structure, molecular genetics and the structure and functions of the cell nucleus in general.
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Specificații

ISBN-13: 9780306478734
ISBN-10: 0306478730
Pagini: 347
Ilustrații: 364 p.
Dimensiuni: 155 x 235 x 26 mm
Greutate: 0.75 kg
Ediția:2004
Editura: Springer Us
Colecția Springer
Seria Molecular Biology Intelligence Unit

Locul publicării:New York, NY, United States

Public țintă

Research

Cuprins

Nucleolar Structure and Organization.Structural organization of the nucleolus as a consequence of the dynamics of ribosome biogenesis.The dynamic  proteome of the nucleolus.The Structure of rDNA Chromatin.The epigenetics of the nucleolus: structure and function of active and silent ribosomal RNA genes.UBF, an Essential Player in Maintenance of Active NORs and nucleolar formation.- Role of the Nucleolus in Ribosome Biogenesis.The RNA Polymerase I Transcription Machinery.Small Ribonucleoproteins in Ribosome Biogenesis.Crosstalk between ribosome synthesis and cell cycle progression and its potential implications in  human genetic disease.The multiple properties and functions of nucleolin.The multifunctional nucleolar protein nucleophosmin/NPM/B23 and the nucleoplasmin family of proteins.Structure and function of NOPP140 and treacle.- Novel Functions of the Nucleolus.The Role of the Nucleolus in the Stress Response.New Frontiers in Nucleolar Research - Nucleostemin and Related Proteins.Viruses and the Nucleolus.Assembly of Signal Recognition Particles in the Nucleolus.Relationship of the Cajal Body to the Nucleolus.Role of the Nucleolus in HIV Infection and Therapy.

Textul de pe ultima copertă

Within the past two decades, extraordinary new functions for the nucleolus have begun to appear, giving the field a new vitality and generating renewed excitement and interest.  These new discoveries include not only the novel functions of the nucleouls, but also numerous breakthroughs on its conventional role.  Consequently, a large part of this volume is devoted to traditional functions of the nucleolus.  Recent research has led to so much information that the subject cannot be fully contained within one volume, so this book has focused on recent progress in specialized topics within the general subject.
<i>The Nucleolus</i> is divided into three parts: nucleolar structure and organization, the role of the nucleolus in ribosome biogenesis, and novel functions of the nucleolus.  Proteomics has shown that there are hundreds of proteins of unknown function in the nucleolus, which are likely to keep researchers busy for years.  In addition, the roles of many viral components in the nucleolus will continue to intrigue us, hopefully moving beyond the phenomenology that is now the case with many viral components in the nucleolus.  Even now, there is already evidence that we can take advantage of our knowledge of the nucleolus to develop therapeutic strategies, and this book hopes to help build the path to a new era of nucleolar translational medical research.

Caracteristici

Covers recent discoveries on novel functions of the nucleolus. Emphasizes nucleolar proteins while also including the crucial importance of nucleic acids. Includes chapters on nucleolar ultrastructure, the locations and dynamics of nucleolar components, and on regulatory systems. Includes supplementary material: sn.pub/extras