Cantitate/Preț
Produs
Total produse
Vezi coșul
Transforming Growth Factor-Beta in Cancer Therapy, Volume I: Basic and Clinical Biology de Sonia B. Jakowlew

Transforming Growth Factor-Beta in Cancer Therapy, Volume I: Basic and Clinical Biology: Cancer Drug Discovery and Development

Editat de Sonia B. Jakowlew Cuvânt înainte de M.B. Sporn
en Limba Engleză Paperback – 19 noi 2010
Transforming Growth Factor-jl in Cancer Therapy, Volume I: Basicand Clinical Biology The present volume brings together a wealth of information that is fundamental to understanding the roleofTGF-~ in the pathogenesis, prevention, and treatment of cancer. It is not even 25 years sinceTGF-~ was first isolated and characterized as a dimeric pep­ tide from both human and bovine sources (1-3), but the entire fieldofTGF-~ research has grown and expanded so that it is now a central theme in all of cell biology. There is almost no tissue or organ in the mammalian body in whichTGF-~ does not playa central role in embryonic differentiation or in adult function, and furthermore, malfunction of the normal physiologyofTGF-~can have disastrous consequences in almost all ofthese sites. Therefore, the present comprehensive review of so many aspects ofTGF-~ function is a most welcome attempt to bring together a huge body of experimental data that is of the utmost importance in the field of oncology.
Citește tot Restrânge

Toate formatele și edițiile

Toate formatele și edițiile Preț Express
Paperback (1) 154772 lei  6-8 săpt.
  Humana Press Inc. – 19 noi 2010 154772 lei  6-8 săpt.
Hardback (1) 138372 lei  6-8 săpt.
  Humana Press Inc. – 28 feb 2008 138372 lei  6-8 săpt.

Din seria Cancer Drug Discovery and Development

  • 5% CNS Cancer: Models, Markers, Prognostic Factors, Targets, and Therapeutic Approaches
    Preț: 139689 lei
  • 5% Developments in T Cell Based Cancer Immunotherapies
    Preț: 104973 lei
  • 5% mTOR Pathway and mTOR Inhibitors in Cancer Therapy
    Preț: 134080 lei
  • 5% Antiangiogenic Agents in Cancer Therapy
    Preț: 137019 lei
  • 5% Tumor Models in Cancer Research
    Preț: 137541 lei
  • 5% Telomeres and Telomerase in Cancer
    Preț: 131674 lei
  • 5% Gene Therapy for Cancer
    Preț: 136330 lei
  • 5% Proteasome Inhibitors in Cancer Therapy
    Preț: 105400 lei
  • 5% Oncogene-Directed Therapies
    Preț: 106668 lei
  • 24% Protein Tyrosine Kinases: From Inhibitors to Useful Drugs
    Preț: 103759 lei
  • 5% Cancer Chemoprevention: Volume 2: Strategies for Cancer Chemoprevention
    Preț: 138872 lei
  • 5% Apoptosis, Senescence and Cancer
    Preț: 135078 lei
  • 5% Bioinformatics in Cancer and Cancer Therapy
    Preț: 134252 lei
  • 5% Bone Metastasis
    Preț: 105458 lei
  • 5% Nitric Oxide (NO) and Cancer: Prognosis, Prevention, and Therapy
    Preț: 135293 lei
  • 5% Tumor Suppressor Genes in Human Cancer
    Preț: 135411 lei
  • 5% Platinum-Based Drugs in Cancer Therapy
    Preț: 74082 lei
  • 5% Regional Cancer Therapy
    Preț: 136243 lei
  • 5% Checkpoint Controls and Targets in Cancer Therapy
    Preț: 105088 lei
  • 5% Antifolate Drugs in Cancer Therapy
    Preț: 135847 lei
  • 5% Transforming Growth Factor-Beta in Cancer Therapy, Volume II: Cancer Treatment and Therapy
    Preț: 136582 lei
  • 5% Transforming Growth Factor-Beta in Cancer Therapy, Volume I: Basic and Clinical Biology
    Preț: 138372 lei
  • 5% Farnesyltransferase Inhibitors in Cancer Therapy
    Preț: 104832 lei
  • 5% Supportive Care in Cancer Therapy
    Preț: 98218 lei
  • 5% Nucleic Acid Therapeutics in Cancer
    Preț: 68941 lei
  • 5% Stem Cells and Cancer
    Preț: 133176 lei
  • 5% EGFR Signaling Networks in Cancer Therapy
    Preț: 129740 lei
  • 5% Hematopoietic Growth Factors in Oncology: Basic Science and Clinical Therapeutics
    Preț: 106512 lei
  • 5% Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy
    Preț: 135723 lei
  • 5% Hormone Therapy in Breast and Prostate Cancer
    Preț: 105213 lei
  • 5% Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy: Molecular Mechanisms and Clinical Applications
    Preț: 131776 lei
  • 5% The Oncogenomics Handbook
    Preț: 138735 lei
  • 5% Macromolecular Anticancer Therapeutics
    Preț: 183685 lei
  • 5% Histone Deacetylases: Transcriptional Regulation and Other Cellular Functions
    Preț: 134338 lei
  • 5% Cancer Drug Resistance
    Preț: 136277 lei
  • 5% Matrix Metalloproteinase Inhibitors in Cancer Therapy
    Preț: 104210 lei
  • 5% Fluoropyrimidines in Cancer Therapy
    Preț: 105126 lei
  • 5% In Vivo Imaging of Cancer Therapy
    Preț: 99058 lei
  • 5% The Tumor Microenvironment
    Preț: 136674 lei
  • 5% Camptothecins in Cancer Therapy
    Preț: 135327 lei
  • 5% Targets for Cancer Chemotherapy: Transcription Factors and Other Nuclear Proteins
    Preț: 74600 lei
  • 5% Cancer Proteomics: From Bench to Bedside
    Preț: 131172 lei
  • 5% Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response
    Preț: 133176 lei
  • 5% COX-2 Blockade in Cancer Prevention and Therapy
    Preț: 105424 lei
  • 5% Cytokines in the Genesis and Treatment of Cancer
    Preț: 136353 lei

Preț: 154772 lei

Preț vechi: 162918 lei
-5% Nou

Puncte Express: 2322
Preț estimativ în valută:
29630€ • 32297$ • 24914£

Carte tipărită la comandă

Livrare economică 17-31 decembrie

 Adaugă în coș

Wish list
Gift list
Am citit!
Adaugă în listă
Preluare comenzi: 021 569.72.76

Specificații

ISBN-13: 9781617377358
ISBN-10: 161737735X
Pagini: 735
Ilustrații: XXIV, 735 p.
Greutate: 1.29 kg
Ediția:Softcover reprint of hardcover 1st ed. 2008
Editura: Humana Press Inc.
Colecția Humana
Seria Cancer Drug Discovery and Development

Locul publicării:Totowa, NJ, United States

Public țintă

Research

Cuprins

Basic Concepts of TGF-? Signaling in Normal Physiology and Cancer Pathobiology.- Component Hardware for Transforming Growth Factor-? Signal Transduction: TGF-? Ligands, TGF-? Receptors, and Smads.- TGF-? Signaling in Homeostasis and Cancer.- TGF-? Availability: Latent TGF-? and Latent TGF-? Binding Proteins.- Biological Functions of Latent TGF-?-Binding Proteins and Activation of TGF-?.- Regulators of Smad2/3 Transcription and Phosphorylation.- Interaction of Smad4 and Embryonic Liver Fodrin-?-spectrin in Hyperplasia, Neoplasia, and Tumor Suppression.- Regulation of Smad Activity by Phosphorylation.- Nuclear Targeting of TGF-?-Activated Smads in Normal and Tumor Biology.- Ski, SnoN, and Akt as Negative Regulators of Smad Activity: Balancing Cell Death and Cell Survival.- Transforming Growth Factor-? in Cancer Therapy: Smurfs in TGF-? Signaling and Regulation of Bone Homeostasis and Cancer.- Involvement of km23 Dynein Light Chains in TGF ? Signaling.- TGF-? Signaling in Fibroblastic Cells and Oncogenesis.- Mechanisms of TGF-?-Induced Apoptosis in Cancer Cells.- Mechanisms of Cell Cycle Regulation by TGF-? Disabled in Cancer.- Transforming Growth Factor-? in Cancer Therapy.- TGF-? and Smad Signaling in Transcriptome Reprogramming During EMT.- Functional Interactions Between MMPs and TGF-? in Normal and Tumor Tissue.- Cooperation Between TGF-? and Wnt Pathway Components in Regulating Mesenchymal Stem Cell Function.- Interaction of Oncogenic Ras and TGF?1 Signaling in Cancer: Lessons From the Multistage Skin Carcinogenesis Model.- TGF-? Superfamily Members in Normal and Tumor Biology.- Proteomics Analysis of TGF? Superfamily Members.- Mullerian Inhibiting Substance: A Potential Nontoxic, Naturally Occurring Therapeutic Agent for Certain HumanCancers.- Activins, Inhibins, and Bone Morphogenetic Proteins as Modulators and Biomarkers of Prostate Cancer Progression.- Bone Morphogenic Proteins and Angiogenesis in Developing Tumors.- Histone Methyltransferase and Smad Interactions in BMP Signaling.- Endoglin (CD105): A Strong Candidate for Immunologic Targeting of Tumor Neovasculature in Human Malignancies.- Activins and Inhibins in Cancer Progression.- Bone Morphogenetic Proteins/Growth Differentiation Factors and Smad Activation in Ovarian Granulosa Cells and Carcinoma.- Regulation of the Transforming Growth Factor-? Superfamily by Betaglycan.- Uterine Sensitization Associated Gene-1: A Bone Morphogenetic Protein Antagonist with a Role in Kidney.- Role of Betaig-h3 Gene in Carcinogenesis.- Activins and the Liver.- Myostatin Signaling in Normal and Tumor Cells.- TGF-? in Inflammation and Fibrosis.- Triterpenoids, Vitamin D, and TGF-?/Smad Signaling in Inflammation and Cancer.- Thrombospondin-Dependent Activation of Latent TGF-? in Fibrosis and Disease.- TGF-? in Pulmonary Fibrosis.- The Role of TGF-? in Bleomycin Induced Pulmonary Fibrosis.- Smads in the Fibrotic Response: Findings in the Smad3 Knockout Mouse.- TGF-? Signaling in Renal Fibrosis and Inflammation: Gene Therapy Using Ultrasound-Microbubble-Mediated Inducible Smad7.- Transforming Growth Factor-? Peptide Signaling in Pulmonary Development, Bronchopulmonary Dysplasia, Fibrosis, and Emphysema.- The Role of TGF-? in Radiation and Chemotherapy Induced Pulmonary Fibrosis: Inhibition of TGF-? as a Novel Therapeutic Strategy.- Negative Regulation of the TGF-? Family Signal Pathway by Inhibitory Smads and Their Involvement in Cancer and Fibrosis.- TGF-?-Related Antifibrotic Strategies in the Eye.- Transforming Growth Factor-? in CutaneousTissue Repair.- Topical Application of TGF-?1 Peptide Inhibitors for the Therapy of Skin Fibrosis.- Overexpressed Truncated TGF-? Type II Receptor Inhibits Fibrotic Behavior of Keloid Fibroblasts In Vitro and Experimental Scar Formation In Vivo.

Recenzii

From the reviews:
"This volume provides a comprehensive review of TGF-beta regulation, signaling, and cellular function in both normal and tumor biology. … will be of use to individuals interested in the role of TGF-beta in the development of cancer and fibrosis. This will likely benefit readers interested in TGF-beta in the pathogenesis of disease … . also be a resource for those interested in the complex intracellular signaling cascades elicited by TGF-beta in normal and altered cells." (James P Luyendyk, Doody’s Review Service, May, 2008)

Textul de pe ultima copertă

Transforming Growth Factor-ß in Cancer Therapy, Volumes 1 and 2, provide a compendium of findings about the role of transforming growth factor-ß (TGF-ß) in cancer treatment and therapy. The first volume, Basic and Clinical Biology, is divided into three parts. Part I presents basic concepts of transforming growth factor-ß signaling in normal physiology and cancer pathobiology. Part II investigates transforming growth factor-ß superfamily members in normal and tumor biology. Part III details transforming growth factor-ß in inflammation and fibrosis.
This volume’s companion, Cancer Treatment and Therapy, examines transforming growth factor-ß in several developing and advanced cancers and discusses methods of treatment and therapy. Together, Transforming Growth Factor-ß in Cancer Therapy, Volumes 1 and 2, provide researchers and clinicians with a comprehensive and cutting-edge reference for the findings about the role of transforming growth factor-ß in biology and cancer treatment.

Caracteristici

In-depth detail of basic concepts of TGF-ß in normal physiology and cancer pathobiology Conveniently divided into three easy-to-follow parts Companion volume details cancer treatments and therapies