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Using Mass Spectrometry for Drug Metabolism Studies

Editat de Walter A. Korfmacher
en Limba Engleză Paperback – 15 oct 2019
The first edition of this now classic work helped to establish mass spectrometry as the premier tool for drug metabolism studies. Completely rewritten from start to finish, Using Mass Spectrometry for Drug Metabolism Studies, Second Edition brings medicinal chemists and mass spectrometry professionals up to speed with the rapid advances in the field, the emergence of cutting-edge approaches, and ways to meet steadily increasing vendor demands. Written by international scientists who are experts in their respective disciplines, this state-of-the-art reference effectively encapsulates current mass spectrometry best practices.




The stand-alone chapters cover various topics – from metabolite identification to fast chromatography with UPLC – and in a style that is understandable to experts and field newcomers alike. The second edition of this bestseller includes coverage of new instrumentation and software as well as a wealth of updated information on the latest findings surrounding biomarkers and metabolomics and new chapters on both UPLC and DESI/DART.




With more than 180 illustrations and an eight-page color insert, this valuable reference explores multiple modern mass spectrometry techniques and strategies. It includes an excellent overview of the entire drug discovery process plus the latest developments on how mass spectrometry is used to support this endeavor.
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Specificații

ISBN-13: 9780367384951
ISBN-10: 0367384957
Pagini: 451
Dimensiuni: 156 x 234 mm
Greutate: 0.83 kg
Ediția:2
Editura: CRC Press
Colecția CRC Press

Public țintă

Academic and Professional Practice & Development

Cuprins

Strategies and Techniques for Bioanalytical Assays as Part of New Drug Discovery. The Drug Discovery Process: From Molecules to Drugs. PK Principles and PK/PD Applications. Mass Spectrometry for In Vitro ADME Screening. Metabolite Identification Strategies and Procedures. Reactive Metabolite Screening and Covalent-Binding Assays. Fast Metabolite Screening in a Discovery Setting. Fast Chromatography with UPLC and Other Techniques. Supercritical Fluid Chromatography–Mass Spectrometry. Biomarkers of Efficacy and Toxicity: Discovery and Assay. Imaging Mass Spectrometry for Small Molecules. MALDI IMS for Proteins and Biomarkers. Ambient Ionization Methods and Their Early Applications in ADME Studies. Pharmaceutical Applications of Accelerator Mass Spectrometry.

Descriere

The first edition of this now classic work helped establish mass spectrometry as the premier tool for drug metabolism studies. Keeping pace with rapid advances, the emergence of new approaches, and increasing demands by vendors, the second edition of this bestseller includes cutting-edge coverage of new instrumentation and software as well as significant new information on the latest findings regarding biomarkers and metabolomics. In addition to exploring all modern techniques and strategies, it offers an excellent overview of the entire drug discovery process, including the latest developments in molecular research.