Using Mass Spectrometry for Drug Metabolism Studies
Editat de Walter A. Korfmacheren Limba Engleză Hardback – 3 noi 2009
The stand-alone chapters cover various topics – from metabolite identification to fast chromatography with UPLC – and in a style that is understandable to experts and field newcomers alike. The second edition of this bestseller includes coverage of new instrumentation and software as well as a wealth of updated information on the latest findings surrounding biomarkers and metabolomics and new chapters on both UPLC and DESI/DART.
With more than 180 illustrations and an eight-page color insert, this valuable reference explores multiple modern mass spectrometry techniques and strategies. It includes an excellent overview of the entire drug discovery process plus the latest developments on how mass spectrometry is used to support this endeavor.
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Specificații
ISBN-13: 9781420092202
ISBN-10: 1420092200
Pagini: 452
Ilustrații: 174 b/w images, 12 color images, 24 tables and 100-200 equations
Dimensiuni: 156 x 234 x 28 mm
Greutate: 0.76 kg
Ediția:2Revizuită
Editura: CRC Press
Colecția CRC Press
ISBN-10: 1420092200
Pagini: 452
Ilustrații: 174 b/w images, 12 color images, 24 tables and 100-200 equations
Dimensiuni: 156 x 234 x 28 mm
Greutate: 0.76 kg
Ediția:2Revizuită
Editura: CRC Press
Colecția CRC Press
Public țintă
Academic and Professional Practice & DevelopmentCuprins
Strategies and Techniques for Bioanalytical Assays as Part of New Drug Discovery. The Drug Discovery Process: From Molecules to Drugs. PK Principles and PK/PD Applications. Mass Spectrometry for In Vitro ADME Screening. Metabolite Identification Strategies and Procedures. Reactive Metabolite Screening and Covalent-Binding Assays. Fast Metabolite Screening in a Discovery Setting. Fast Chromatography with UPLC and Other Techniques. Supercritical Fluid Chromatography–Mass Spectrometry. Biomarkers of Efficacy and Toxicity: Discovery and Assay. Imaging Mass Spectrometry for Small Molecules. MALDI IMS for Proteins and Biomarkers. Ambient Ionization Methods and Their Early Applications in ADME Studies. Pharmaceutical Applications of Accelerator Mass Spectrometry.
Descriere
The first edition of this now classic work helped establish mass spectrometry as the premier tool for drug metabolism studies. Keeping pace with rapid advances, the emergence of new approaches, and increasing demands by vendors, the second edition of this bestseller includes cutting-edge coverage of new instrumentation and software as well as significant new information on the latest findings regarding biomarkers and metabolomics. In addition to exploring all modern techniques and strategies, it offers an excellent overview of the entire drug discovery process, including the latest developments in molecular research.