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Venoms to Drugs de David E. Thurston

Venoms to Drugs: RSC Drug Discovery, cartea 42

David E. Thurston Editat de Glenn F. King
en Limba Engleză Hardback – 9 feb 2015
A volume that will provide a comprehensive and up-to-date review on the potential of peptides and proteins from animal venoms as human therapeutics. Topics covered will include: the evolution and ecology of venomous animals; the chemistry and structural biology of animal venoms; venom-based drug discovery: proteomic and transcriptomic approaches; bioassays, high-throughput screening methods and target identification; reptile, cone snail, scorpion, spider-venom peptides and exotic venoms as a platform for drug development; selected case study examples such as Prialt® and Xen2174, exenatide and ShK; the development of venom natriuretic peptides for treating congestive heart failure; engineering venom peptides to improve their stability and bioactivity and manufacturing of venom-derived therapeutic peptides, prospects and pitfalls. The readership will be pharmacologists, toxicologists, biochemists and pharmaceutical scientists working in drug development and the chemical sciences in both industry and academia.
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Specificații

ISBN-13: 9781849736633
ISBN-10: 1849736634
Pagini: 337
Ilustrații: illustrations
Dimensiuni: 160 x 234 x 23 mm
Greutate: 0.64 kg
Editura: Royal Society Of Chemistry
Seria RSC Drug Discovery

Notă biografică

Professor Glenn King has been working on animal venoms since 1996. He has extensive experience in the discovery, production, and structural and functional characterization of venom proteins, and is intimately aware of the issues surrounding their development as drugs and insecticides. In 2006, Professor King founded an agricultural biotechnology company, Vestaron Corporation, that is developing spider-venom peptides discovered in the lab as bioinsecticides. His current research is largely focussed on the development of venom peptides as analgesics for the treatment of chronic pain.

Textul de pe ultima copertă

The pharmaceutical industry has become increasingly interested in biologics from animal venoms as a potential source for therapeutic agents in recent years, with a particularly emphasis on peptides. To date six drugs derived from venom peptides or proteins have been approved by the FDA, with nine further agents currently being investigated in clinical trials. In addition to these drugs in approved or advanced stages of development, many more peptides and proteins are being studied in varying stages of preclinical development. This unique book provides an up to date and comprehensive account of the potential of peptides and proteins from animal venoms as possible therapeutics. Topics covered include chemistry and structural biology of animal venoms, proteomic and transcriptomic approaches to drug discovery, bioassays, high-throughput screens and target identification, and reptile, scorpion, spider and cone snail venoms as a platform for drug development. Case studies are used to illustrate methods and successes and highlight issues surrounding administration and other important lessons that have been learnt from the development of approved therapeutics based on venoms. The first text to focus on this fascinating area and bridging an important gap, this book provides the reader with essential and current knowledge on this fast-developing area. Venoms to Drugs will find wide readership with researchers working in academia and industry working in all medicinal and pharmaceutical areas.