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Zic family: Evolution, Development and Disease de Jun Aruga

Zic family: Evolution, Development and Disease: Advances in Experimental Medicine and Biology, cartea 1046

Editat de Jun Aruga
en Limba Engleză Paperback – 11 feb 2019
This book provides a comprehensive overview of ZIC-family research. Part1 summarizes the ZIC family in animal evolution and development and presents an overall picture of the ZIC family gene structure in eumetazoan animals, providing an evolutionary hypothesis and reviewing the studies on the role of ZIC family proteins in developmental processes for each animal model. Part 2 shows that the ZIC family are the causative genes for developmental disorders, and discusses the role of the ZIC family in stem cell biology. It also presents studies on the ZIC family in the medical biology field. This interdisciplinary book is a valuable resource not only for those people directly involved in ZIC-family-related research, but also researchers in diverse research fields who are interested in the latest advances in biology and medicine. 
 
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Specificații

ISBN-13: 9789811356179
ISBN-10: 9811356173
Pagini: 380
Ilustrații: X, 380 p. 105 illus., 69 illus. in color.
Dimensiuni: 155 x 235 mm
Greutate: 0.64 kg
Ediția:Softcover reprint of the original 1st ed. 2018
Editura: Springer Nature Singapore
Colecția Springer
Seria Advances in Experimental Medicine and Biology

Locul publicării:Singapore, Singapore

Cuprins

Part1: Zic family in animal evolution and development. Comparative genome analysis of Zic genes.- Drosophila Zic genes.- Nematode Zic genes.- Planarian Zic genes.- Ascidian  (Halocynthia) Zic genes.- Ascidian  (Ciona) Zic genes.- Amphibian Zic genes.- Teleost fish  (Oryzias) Zic genes.- Teleost fish (Danio) Zic genes.- Overview of rodent Zic genes.- Rodent Zic genes in neural network wiring.- Rodent Zic genes in meninx and vasculature development.- Part2　ZIC family in Medicine: ZIC family as the causative genes for developmental disorders. ZIC1 in Dandy-Walker malformation.- ZIC2 in holoprosencephaly  Maximilian.- Ch.16 ZIC3 in heterotaxy.- Part3　ZIC family in Medicine: ZIC family in stem cell biology. Role of Zic family in transcriptional regulation and chromatin remodeling.- Deregulation of ZIC family in oncogenesis.- ZIC family and stemness.-  ZIC2 in cancer stem cell.

Notă biografică

Jun Aruga is a professor of pharmacology at Nagasaki University Institute of Biomedical Sciences, and a former head of the Laboratory for Behavioral and Developmental Disorder at RIKEN Brain Science Institute. He has been researching the biological significance of ZIC family genes since their discovery in 1991.

Textul de pe ultima copertă

This book provides a comprehensive overview of ZIC-family research. Part1 summarizes the ZIC family in animal evolution and development and presents an overall picture of the ZIC family gene structure in eumetazoan animals, providing an evolutionary hypothesis and reviewing the studies on the role of ZIC family proteins in developmental processes for each animal model. Part 2 shows that the ZIC family are the causative genes for developmental disorders, and discusses the role of the ZIC family in stem cell biology. It also presents studies on the ZIC family in the medical biology field. This interdisciplinary book is a valuable resource not only for those people directly involved in ZIC-family-related research, but also researchers in diverse research fields who are interested in the latest advances in biology and medicine.   

Caracteristici

Is the first comprehensive review of the Zic family-related studies in biology and medicine Presents the Zic genes for the nervous system appearance is utilized in the animal evolution Provides the cutting edge information for common genetic disorders, stem cell and cancer cell biology