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Biomarker Methods in Drug Discovery and Development: Methods in Pharmacology and Toxicology

Editat de Feng Wang
en Limba Engleză Hardback – 11 mar 2008
The pharmaceutical industry has faced many significant challenges since the early 1990s. The fundamental issue that needs to be addressed is how to improve the efficiency of drug discovery and development. The current research and development (R&D) cost for developing a new therapeutic drug is greater than $800 million. Additionally, it takes an average of 12 years to get a new drug to market with an attrition rate greater than 90%. Reviewing the overall pharmaceutical R&D process, it has become clear that many of the drug failures are due to our lack of knowledge in population diversity, which is responsible for differences in drug efficacy and toxicity. In fact, not a single approved drug is 100% safe and efficacious for all patients. For researchers, the key question is: How can we discover biomarkers that can be used to distinguish patients who will respond to the drug without adverse effects from those who will not respond and/or will have adverse effects? There is tremendous urgency to address this question. Biomarkers also fit perfectly with the vision of personalized medicine, the new expectation of medical practice. This is why biomarker research has been a central focus in many research labs across academia, government agencies, and the pharmaceutical industry. There are many different ways to define biomarkers based on molecular properties, applications, and methods.
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Specificații

ISBN-13: 9781934115237
ISBN-10: 1934115231
Pagini: 520
Ilustrații: XVIII, 396 p. 88 illus., 9 illus. in color.
Dimensiuni: 155 x 235 x 28 mm
Greutate: 0.82 kg
Ediția:2008
Editura: Humana Press Inc.
Colecția Humana
Seria Methods in Pharmacology and Toxicology

Locul publicării:Totowa, NJ, United States

Public țintă

Research

Cuprins

Biomarker Sample Collection and Handling in the Clinical Setting to Support Early-Phase Drug Development.- Gene Expression-Based Biomarkers of Drug Safety.- Profiling Gene Expression Signatures Using Fluorescent Microspheres.- Real-Time Polymerase Chain Reaction Gene Expression Assays in Biomarker Discovery and Validation.- SAGE Analysis in Identifying Phenotype Single Nucleotide Polymorphisms.- Single Nucleotide Polymorphisms and DNA Methylation Analysis Using Pyrosequencing Methods.- The Application of Laser Capture Microdissection for the Analysis of Cell-Type-Specific Gene Expression in a Complex Tissue:.- The Use of Two-Dimensional Gel Electrophoresis for Plasma Biomarker Discovery.- Difference In-Gel Electrophoresis: A High-Resolution Protein Biomarker Research Tool.- Label-Free Mass Spectrometry-Based Protein Quantification Technologies in Protein Biomarker Discovery.- Top-Down Quantitative Proteomic Analysis Using a Highly Multiplexed Isobaric Mass Tagging Strategy.- SELDI Technology for Identification of Protein Biomarkers.- Sandwich ELISA Microarrays: Generating Reliable and Reproducible Assays for High-Throughput Screens.- LC-MS Metabonomics Methodology in Biomarker Discovery.- GC-MS-Based Metabolomics.- NMR-Based Metabolomics for Biomarker Discovery.- Unraveling Glycerophospholipidomes by Lipidomics.

Recenzii

From the reviews:
"... extremely useful to pharmaceutical scientists who are involved in research all the way from early drug discovery through clinical trials." - Doody's Book Review
"The book is … for the bench scientist and is full of helpful advice on how to achieve high quality data using up-to-date technical approaches in genomics, proteomics and metabonomics. … I warmly recommend this … to all practicing toxicologists." (Roy Forster, British Toxicological Society Newsletter, June-August, 2009)

Textul de pe ultima copertă

Within the pharmaceutical industry, the improvement of drug discovery and development efficiency and the expected personalization of medicine have become vitally important issues.  In Biomarker Methods in Drug Discovery and Development, expert researchers provide a tool box for those who have a general interest in biomarker research and for those currently specializing in certain technologies but desiring an understanding of other available methodologies.  Its chapters include validated, mature methods as well as new, incredibly promising protocols which aim to apply multiple technologies at different molecular levels in order to surmount the monumental and complex task of transforming the pharmaceutical research and development processes.  As a volume in the Methods in Pharmacology and Toxicology™ series, this book offers user-friendly, step-by-step laboratory protocols for readily reproducible experiments.
Comprehensive and state-of-the-art, Biomarker Methods in Drug Discovery and Development is the perfect biomarker technical guideline and reference to stimulate more exciting biomarker research and technology development.

Caracteristici

Broad coverage of proven and practical biomarker techniques currently applied in drug discovery and development Multiple biomarker analysis methods for each of the different molecular levels Real biomarker applications from early discovery to clinical trials Detailed sample handling and preparation techniques to ensure successful biomarker studies